Searchable abstracts of presentations at key conferences in endocrinology

ea0020oc6.6 | Paediatric Endocrinology/Bone | ECE2009

Reduced selenoprotein P expression affects bone formation

Hog Antonia , Renko Kostja , Seemann Petra , Kornak Uwe , Schomburg Lutz

Selenium (Se) is an essential trace element and is important for maintaining health and preventing disease. Se exhibits its biological function as the 21st proteinogenic amino acid selenocysteine (Sec). Different cis and trans acting factors are necessary for incorporation of Sec into proteins. Se can be transported and stored as Sec in selenoprotein P (SePP), a liver-derived protein which contains up to 10 Sec residues per protein in humans. Thus, SePP functions...