Searchable abstracts of presentations at key conferences in endocrinology

ea0007p190 | Reproduction | BES2004

Mullerian Inhibiting Substance is elevated in obese women with PCOS and is suppressed by metformin treatment

Fleming R , Harborne L , MacLaughlin D , Ling D , Norman J , Sattar N , Seifer D

Mullerian Inhibiting Substance (MIS) is a member of the transforming growth factor beta superfamily of growth factors, which causes regression of the Mullerian duct in male embryos, and is believed to act in a paracrine fashion after birth to regulate granulosa cell and oocyte function. MIS appears to be an important regulator of primordial follicle recruitment, and is also capable suppressing androgen production. Abnormal ovarian function is implicit in polycystic ovary syndr...