Endocrine Abstracts

Introduction: Hypothalamus or pituitary disorders frequently cause hypopituitarism. Diagnosing deficits of anterior pituitary hormones is important to manage metabolic impairments induced by hypopituitarism. Provocative tests including TRH, LHRH, CRH and GHRP-2 to diagnose hypopituitarism are recommended in Japan, however, the cut-off values in those tests are not adjusted for age, body mass index (BMI) or estimated glomerular filtration rate (eGFR). We retrospectively evaluat...

Background: Growth hormone (GH) deficiency, which causes visceral obesity and non-alcohol fatty liver disease, increases cardiovascular event risks. High-sensitivity C-reactive protein (hs-CRP), an inflammatory marker associated with increased cardiovascular risk, reportedly decreased after GH supplementation in GH-deficient patients, however, the association between GH secretion and inflammation remains unclear.Patients and Methods: We retrospectively i...

Background: Primary hyperparathyroidism (PHPT) reduces bone mineral density (BMD), leading to secondary osteoporosis. While parathyroidectomy has been reported to increase BMD, the efficacy of medical therapy for PHPT-induced osteoporosis after parathyroidectomy remains uncertain. Herein, we report two PHPT cases with osteoporosis, where romosozumab, an anti-sclerostin monoclonal antibody, increased BMDs after parathyroidectomy.Case 1: A 67-year-old woma...

Background: (Pro)renin receptor[(P)RR] is a multi-functioning transmembrane protein which plays key roles in the regulation of tissue renin-angiotensin system (RAS). (P)RR is cleaved by furin to generate soluble (P)RR[s(P)RR], which is secreted into extracellular space. We previously reported that high blood concentration of s(P)RR indicates poor organ prognosis in several diseases. In this way, s(P)RR is expected as a candidate biomarker for reflecting the tissue RAS status, ...

Introduction: Sarcoidosis is a systemic granulomatous disorder usually affects multiple organs. Approximately 10% of sarcoidosis occurs as isolated neurosarcoidosis in CNS and <10% of neurosarcoidosis develops in a restricted hypothalamic–pituitary area. Recent study has identified Propionibacterium acnes in lungs and lymph nodes of many patients with sarcoidosis using a MAB specific for this bacterium (PAB), providing strong evidence for P. acne as ...

Background: Growth hormone (GH) deficiency causes visceral obesity and fatty liver and increases cardiovascular event risks. Because serum high-sensitivity C-reactive protein (hs-CRP) levels, which has been used to estimate those risks, was reported to be decreased by GH supplementation therapy in GH deficient patients, it has been suggested that inflammatory processes might be activated in GH deficient state. However, the clinical factors associated with increased hs-CRP leve...

Objective: The efficacy of mineralocorticoid receptor (MR) antagonists has been demonstrated in MR-related hypertension, including primary aldosteronism (PA). Non-inferiority in 24-hour blood pressure reduction has been shown for esaxerenone 2.5 mg/day compared to eplerenone 50 mg/day in patients with essential hypertension. However, no trial has compared the antihypertensive effects of these drugs in patients with PA. This study aimed to investigate the effect of switching fr...

Introduction: Acromegaly hardly complicates hypercortisolemia due to co-over-secretion of ACTH from the pituitary tumor. Herein, we present a case of acromegaly with hypercortisolemia.Clinical case: A 68-year-old woman visited a local clinic due to bitemporal visual field defects. A magnetic resonance imaging scan of the pituitary gland showed a 25 mm-sized mass extending from the sellar to the suprasellar region, and she was referred to our hospital for...

Introduction: TSH-secreting pituitary adenoma (TSHoma) sometimes brings on rare cause of hyperthyroidism because of its excessive TSH secretion. Though the first line of treatment for TSHoma is surgical removal of tumour, hyperthyroidism often causes perioperative thyroid storm. Here, we report a case of GH-TSH pituitary adenoma whose thyrotoxicosis was controlled by 5 days’ octoreotide (OCT) subcutaneous administration before surgery.Case report: A...