ea0063p15 | Adrenal and Neuroendocrine Tumours 1 | ECE2019
, Selivanova Lilya
, Platonova Nadezhda
, Troshina Ekaterina
, Abrosimov Aleksandr
Introduction: CYP11B2 is a key enzyme of primary aldosteronism, and several factors are involved in the regulation of CYP11B2 expression and the overproduction of aldosterone. Somatic mutations in aldosterone-driver genes are strongly associated with CYP11B2 expression and have been only detected in the CYP11B2-positive tumor area, indicating that aldosterone producing adenoma (APA) intratumoral heterogeneity corresponds to non-uniform CYP11B2 expression in neoplastic cells. I...