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ea0063p15 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Immunohistochemical characteristics of adrenal tumors in patients with primary aldosteronism

Romanova Natalia , Selivanova Lilya , Platonova Nadezhda , Troshina Ekaterina , Abrosimov Aleksandr

Introduction: CYP11B2 is a key enzyme of primary aldosteronism, and several factors are involved in the regulation of CYP11B2 expression and the overproduction of aldosterone. Somatic mutations in aldosterone-driver genes are strongly associated with CYP11B2 expression and have been only detected in the CYP11B2-positive tumor area, indicating that aldosterone producing adenoma (APA) intratumoral heterogeneity corresponds to non-uniform CYP11B2 expression in neoplastic cells. I...