Searchable abstracts of presentations at key conferences in endocrinology

ea0011p893 | Thyroid | ECE2006

Cytostatic effect of plitidepsin (AplidinTM) in human undifferentiated (anaplastic) thyroid carcinoma

Bravo Susana , garcia-renduelles Maria , Seoane Rafael , Dosil Vanesa , Cameselle Jose , Lopez-Lázaro Luis , Zalvide Juan , Barreiro Franci , Pombo Celia , Alvarez Clara

Undifferentiated thyroid carcinoma is a highly aggressive human cancer with poor prognosis. A strong association has been observed between undifferentiated thyroid carcinoma and TP53 mutations. Plitidepsin (AplidinTM) a novel anticancer compound from a sea tunicate, has been reported to induce apoptosis independently of TP53 status. We investigated the actions of plitidepsin in human thyroid cancer cells. initiallyexperiments using primary cultured cells from a d...

ea0014p314 | (1) | ECE2007

A novel pro-migratory action of TGFb in papillary carcinoma

Rodríguez García-Renueles María Elena , Bravo López Susan Belen , Seoane Rafael , Puig Carmen Gil , Teijeiro José Cameselle , Barreiro Francisco , Villamarín Clara Álvarez

Neoplastic thyroid diseases (multinodular goiter (MNG), follicular adenoma, differentiated (DTC) and undifferentiated thyroid carcinoma) have a higher incidence in women than in men. In fact, in the last ten years, DTC is the only cancer increasing the frequency in women, with an incidence similar to ovarian carcinoma or lymphomas.TGFb is a secreted factor important in the normal function of the thyrocyte. It has two independent actions: a fast antiproli...