Searchable abstracts of presentations at key conferences in endocrinology

ea0063p1099 | Pituitary and Neuroendocrinology 3 | ECE2019

Pituitary apoplexy (PA) – a relatively rare condition requiring early recognition, individualized treatment and longterm follow-up

Vladan Andreea , Baranga Iuliana , Niculescu Dan , Radian Serban , Radian Serban , Poiana Catalina

Background: PA is a clinical syndrome secondary to hemorrhage or infarction of pituitary tumour, presenting with sudden onset headache and oculomotor palsy. PA may be managed conservatively in patients without visual disturbances.Aim: To describe PA patients illustrating typical aspects and peculiarities.Results: Case 1, a 49 years old (yo) male, presented for loss of consciousness in the ER. MRI showed a giant pituitary tumour, wh...

ea0034p314 | Pituitary | SFEBES2014

Analysis of the AIP gene promoter

Radian Serban , King Peter , Korbonits Marta

Background: Germline mutations of the AIP tumour suppressor gene are associated with familial and sporadic pituitary adenomas, yet the tumorigenic mechanisms remain unclear. In addition, AIP protein expression in somatotroph adenomas from patients without AIP mutations correlates with clinical behaviour and somatostatin analogues responsiveness. Understanding the regulation of AIP gene expression will help uncover its pituitary tumour-suppressor role.Aim...

ea0090ep742 | Pituitary and Neuroendocrinology | ECE2023

Hyponatremia apparently due to carbamazepine as the initial presentation of panhypopituitarism in a patient with a non-functioning pituitary tumour

Vladan Andreea , Iancu Cristina , Radian Serban , Poiana Catalina

Introduction: Hyponatremia, defined as a serum sodium concentration below 135 mEq/l, has a heterogeneous etiology, the main endocrine causes includind the syndrome of inappropiate antidiuresis (SIAD), adrenal insufficiency and severe hypothyroidism.Materials and methods: Clinical, hormonal and imaging evaluationAim: To present a case of hyponatremia leading to the diagnosis of a large pituitary tumorCase pres...

ea0090ep850 | Pituitary and Neuroendocrinology | ECE2023

Intrasellar arachnoid cysts – a benign entity with significant clinical impact: report of two cases

Iancu Cristina , Vladan Andreea , Bica Dorin , Radian Serban , Poiana Catalina

Introduction: Intrasellar arachnoid cysts are rare and clinically resemble nonfunctional pituitary adenomas. Arachnoid cysts should be considered in the differential diagnosis of cysts developing in the sellar region, together with cystic pituitary adenoma, craniopharyngioma, epidermoid cysts, and Rathke’s cleft cysts. Symptomatic cysts are operated but can recurr.Case presentation: We present 2 cases of compressive intrasellar arachnoid cysts occur...

ea0049ep1067 | Pituitary - Clinical | ECE2017

Nonfunctioning pituitary incidentaloma – delayed onset of acromegaly and concomitant primary adrenocortical insufficiency

Radian Serban , Deciu Diana , Lefter Antonia , Poiana Catalina

Introduction: Pituitary incidentaloma (PitInc), defined as an unsuspected mass observed on imaging studies performed for unrelated conditions. Most such lesions are not clinically significant at initial evaluation and current guidelines recommend periodic follow-up.Aim: To present a rare case of delayed onset of acromegaly in a patient with a nonfunctioning PitInc, raising the question of the utility of prolonged follow-up of PitInc.<p class="abstext...

ea0037ep197 | Reproduction, endocrine disruptors and signalling | ECE2015

The connection between serum prolactin, TSH, and insulin resistance in polycystic ovary syndrome patients

Albu Alice , Radian Serban , Florea Suzana , Fica Simona

Introduction: Both TSH and prolactin serum levels within normal range were previously reported to be associated with metabolic parameters.Aim: To analyse the connections between serum levels of prolactin, TSH, and insulin resistance in polycystic ovary syndrome patients.Material and methods: 322 PCOS patients (mean age 24.3±5.16 years and mean BMI 28±7.57 kg/m2) with normal serum prolactin and without thyroid d...

ea0070aep633 | Pituitary and Neuroendocrinology | ECE2020

ACTH-secreting pituitary tumor with delayed aggressive clinical recurrence – management challenges

Gaita Isabela , Cristescu Alexandru , Enculescu Augustina , Poiana Catalina , Radian Serban

Background: Pituitary adenomas (PA) are slow-growing, benign intracranial tumors. Rarely, they can be histologically and clinically aggressive.Aim: To present a case of corticotroph PA with aggressive behavior following a long indolent interval after the initial surgery.Case presentation: A 47 years old female presented in Nov 2007 with right temporal hemianopsia and left eye blindness, associating type 2 DM and severe mixed dyslip...

ea0031p169 | Neoplasia, cancer and late effects | SFEBES2013

Between genetics, guidelines and treatment in MEN2A: a family affair

Dobrescu Ruxandra , Hortopan Dan , Stanescu Bogdan , Radian Serban , Badiu Corin

The multiple endocrine neoplasia syndrome type 2A (MEN 2A) is the consequence of a heritable mutation in the RET proto-oncogene, leading to a very high predisposition to develop medullary thyroid carcinoma (MTC), pheochromocytoma and primary parathyroid hyperplasia. Screening of ‘at-risk’ family members and prophylactic thyroidectomy is recommended – but not always easily accomplished.Our proband was diagnosed with MTC in 1977 (at age 21),...

ea0090ep762 | Pituitary and Neuroendocrinology | ECE2023

Challenges in the management of prolactinomas: A case of partial resistance to high-dose cabergoline in a young male with an invasive giant prolactinoma

Cheţan Larisa-Nicoleta , Vladan Andreea , Hortopan Dan , Gobej Ionut , Radian Serban , Poiana Catalina

Background: Giant prolactinomas are rare pituitary tumours larger than >40 mm in diameter, representing 2–3% of prolactin secreting tumours. Management is challenging especially in male patients, due to resistance to dopamine agonists (DA).Methods: Clinical, hormonal and imaging evaluation and follow-upAim: To describe a case of partially resistant giant prolactinoma in a young male patientCase repor...

ea0065p64 | Adrenal and Cardiovascular | SFEBES2019

Primary aldosteronism (PA) – clinical and hormonal characteristics of a series of patients

Vladan Andreea , Baranga Iuliana , Dumitrascu Anda , Hortopan Dan , Poiana Catalina , Radian Serban

Background: PA is a frequent cause (5–13%) of secondary hypertension (HT), yet diagnostic work-up of PA remains challenging.Aim: To describe the characteristics of hypertensive patients diagnosed with PA, biochemical screening (aldosterone:renin ratio/ARR), confirmatory tests, and adrenal CT results.Methods: Clinical, hormonal and imaging evaluation.Results: 13 patients (7M/6F) with PA were 45 yrs (40&#1...