Searchable abstracts of presentations at key conferences in endocrinology

ea0014p38 | (1) | ECE2007

Oral antibodies to insulin receptor are found effective in the treatment of streptozotocin-induced diabetes in rats

Dugina Julia , Martyushev-Poklad Andrey , Kheyfets Irina , Spasov Alexander , Samokhina Maria , Epstein Oleg , Sergeeva Svetlana

An experimental study was designed to test a drug candidate for the treatment of diabetes mellitus in rats with streptozotocin (STZ) diabetes.Diabetes was induced in outbred male rats (280–300 g) by single iv injection of streptozotocin 50 mg/kg. The animals showing hyperglycemia (12–15 mM) 72 hours after injection were randomized to receive daily intragastric doses of distilled water, glibenclamid 8 mg/kg, or polyclonal antibodies to C-termina...