Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep76 | Adrenal and Cardiovascular Endocrinology | ECE2022

Pulmonary thromboembolism as the initial presentation of ACTH-independent Cushing’s Syndrome

Dias Daniela , Damasio Ines , Simoes Helder , Serra Filipa , Fontes Luisa , Leichsenring Carlos , Pinheiro Nuno , Sapinho Ines

Cushing’s syndrome (CS) is associated with a considerable risk of complications including thromboembolic events (TE). They occur mostly within the first 2–3 months postoperatively. When present before surgery, CS has high rates of perioperative mortality and morbidity. The benefit of steroidogenesis inhibitors after TE is not fully known. Furthermore, little guidance is available regarding TE assessment/management in CS. We report a case of a 34-year-old male admitte...

ea0049ep139 | Clinical case reports - Pituitary/Adrenal | ECE2017

Gynecomastia in men: A rare case of adrenal feminizing tumors

Duarte Vitoria , Verissimo David , Passos Dolores , Serra Filipa , Silva Joao , Lopes Luis , Castro J.J. , Marcelino Mafalda

Estrogen-producing adrenal gland tumors (EPAGT) are extremely rare, accounting for only 1–2% of all adrenal tumors. They are most commonly observed in men or in children, and are unusual in women. They are almost always malignant even if they seem benign at presentation, and most of them have a poor prognosis. We present a case of a 71-year-old man with painful bilateral gynecomastia, without galactorrhea, over 4 months. Markedly elevated plasma estradiol levels were foun...

ea0049ep951 | Pituitary - Clinical | ECE2017

Acute presentation of cushing disease: severe hyperglycemia and refractory hypokalemia

Bello Carlos Tavares , Santos Francisco Sousa , Ferrinhos Catia , Serra Filipa Alves , Duarte Joao Sequeira , Vasconcelos Carlos

Introduction: Cushing’s syndrome (CS) is a rare disease resulting from prolonged exposure to supraphysiological levels of glucocorticoids. Cushing’s Disease is the most frequent cause of endogenous CS. This disease has a broad spectrum of clinical manifestations and is associated with an increased morbi-mortality. Diabetes Mellitus (DM) and hypokalemic alkalosis affects up to 50 and 10% of CS patients respectively. Disease onset and severity reflects the magnitude of...

ea0049ep1088 | Clinical case reports - Pituitary/Adrenal | ECE2017

Hypogonadotropic hypogonadism, functional and transitory

Roque Catarina , Serra Filipa , Santos Francisco Sousa , Ferrinho Catia , Capitao Ricardo , Bello Carlos , Vasconcelos Carlos

Functional hypogonadism has been described in association with acute severe medical or surgical illness, subacute recovery and chronic disease. We present a case of transitory hypogonadism manifested during a peri-surgical period. A 42-year-old patient was sent to the endocrinology clinic due to hypertension and a solitary adrenal mass. He was treated with bisoprolol and telmisartan, that he maintains until today. The evaluation favoured non-functional adenoma but during the f...

ea0037ep541 | Diabetes (complications & therapy) | ECE2015

Weight and weight variability correlates with subclinical inflammation and comorbidities in diabetes type 2: a retrospective study over the last decade

Roque Catarina , Duarte Sequeira , Ferreira Rute , Serra Filipa , Moniz Catarina , Azinheira Jorge , Vasconcelos Carlos

Background: Management of obesity and overweight greatly improves glycemic control in type 2 diabetic (T2DM) patients and also provides positive impact in other cardiovascular risk factors in this population.Objectives: Evaluate the impact of weight and weight variability in subclinical inflammation and comorbidities of T2DM patients, over the last decade.Methods: Retrospective study of 1900 patients with T2DM, with a minimum of 2 ...

ea0035p539 | Endocrine tumours and neoplasia | ECE2014

Follicular lesion of undetermined significance in thyroid nodules fine needle aspiration cytology: a revision of 95 cases

Moniz Catarina , Ferreira Rute , Serra Filipa , Fonseca Ricardo , Simoes Helder , Saraiva Catarina , Vasconcelos Carlos , Saraiva Antonio

Introduction: The ‘Atypia of Undetermined Significance/Follicular lesion of Undetermined Significance’ (AUS/FLUS) category of the Bethesda Classification for thyroid nodules fine needle aspiration cytology (FNAC) is reserved for specimens that contain cells with architectural and/or nuclear atypia that is not sufficient to be classified as suspicious or malignant. Our objective is to report our experience in the follow-up and outcome of patients with AUS/FLUS in thyr...

ea0035p1105 | Thyroid Cancer | ECE2014

Nonincidentally and incidentally discovered thyroid cancer

Ferreira Rute , Serra Filipa , Moniz Catarina , Fonseca Ricardo , Simoes Helder , Limbert Clotilde , Oliveira Manuela , Saraiva Antonio

Introduction: Increasing incidence of thyroid cancer might be a consequence of an increase detection of subclinical disease. The aim of this study was to compare the clinical and pathologic characteristics of nonincidentally discovered (NID) thyroid cancer with incidentally discovered (ID) on postoperative pathology.Methods: A retrospective medical record review of 104 patients with thyroid cancer was performed. A group I of 69 patients with NID thyroid ...

ea0073aep578 | Reproductive and Developmental Endocrinology | ECE2021

Turner Syndrome–An unusual presentation of normal stature and incomplete puberty

Dias Daniela , Serra FIlipa , Neves Carolina , Real Mendes Leonor , Nogueira Filomena , Sapinho Inês

IntroductionTurner syndrome(TS) is characterized by complete/partial monosomy or by a structural defect in one of X chromosomes. Despite clinical hallmarks of short stature(SS) and gonadal dysgenesis(GD), phenotype is variable and related to underlying chromosomal pattern. Loss of the distal segment of the short arm of x-chromosome(Xp-), including haploinsufficiency of short stature homeobox-containing (SHOX) gene, is thought to be the main factor for gr...

ea0081p276 | Adrenal and Cardiovascular Endocrinology | ECE2022

Adrenal lesions - the importance of a careful evaluation

Dias Daniela , Figueiredo Ines , Duarte Cristina , Serra FIlipa , Leichsenring Carlos , Tavora Isabel , Paulo Fernandes Joao , Sapinho Ines

Most differential diagnoses of unilateral adrenal lesions include non-functional adenoma, adrenocortical carcinoma or pheochromocytoma. Primary adrenal lymphoma(PAL) is an extremely uncommon type of primary extranodal non-Hodgkin’s lymphoma(<1%). Most cases are bilateral (~75%), being unilateral PAL scarcely reported. The apparent unilateral involvement of this entity at presentation, in the CT scan/MRI may difficult the diagnosis, delaying the start of chemotherapy. ...

ea0049ep1359 | Thyroid (non-cancer) | ECE2017

A slow but continuous growth: Case study of a thyroid nodule

Verissimo David , Pires Vitoria , Passos Dolores , Serra Filipa , Silva Joao , Lopes Luis , Castro Joao Jacome de , Marcelino Mafalda

Thyroid nodules are a common clinical finding, with an estimated prevalence of palpable thyroid nodules to be approximately 5% in women and 1% in men. The clinical importance of thyroid nodules rests with the need to exclude thyroid cancer. The prevalence of malignancy reported for palpable thyroid lesions ranges from 5.0% to 6.5%. Patients with benign thyroid nodules are unlikely to suffer morbidity or mortality due to thyroid cancer. A 53 aged man presented with a 20-year hi...