Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep803 | Reproductive and Developmental Endocrinology | ECE2020

TU score: A new proposal for an ultrasound scoring system to predict testicular function

Carlomagno Francesco , Pozza Carlotta , Gianfrilli Daniele , Tenuta Marta , Sesti Franz , Mazzotta Paola , Lenzi Andrea , Isidori Andrea

Background: Testicular ultrasound (US) is routinely employed in the evaluation of reproductive and sexual function. However, its use for characteristics other than testicular volume is hampered by a lack of information on the prognostic value of its findings, that to date have only been incorporated in a score proposed by Lenz et al. in 1993.Objectives: We sought to explore whether testicular US examination can predict spermatogenesis and provid...

ea0063p453 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Risk factors for gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): a case-control study from NETTARE Unit

Feola Tiziana , Sesti Franz , Puliani Giulia , Sbardella Emilia , Cozzolino Alessia , Lenzi Andrea , Faggiano Antongiulio , Isidori Andrea M , Giannetta Elisa

Introduction: GEP-NENs represent a heterogeneous group of neoplasms with increasing incidence in the last years. Pathogenesis and risk factors of sporadic GEP-NENs are not clear and still debated. The aim of this study is to evaluate the main risk factors for sporadic GEP-NENs in patients followed by the NETTARE Unit (NeuroEndocrine TAsk force of of ‘Sapienza’ University of Rome).Methods: We performed a case-control study including 32 consecuti...

ea0081p390 | Endocrine-Related Cancer | ECE2022

Uncovering the immune profile in well-differentiated gastroenteropancreatic neuroendocrine tumors

Sesti Franz , Puliani Giulia , Sciarra Francesca , Feola Tiziana , Centello Roberta , Di Vito Valentina , Pandozzi Carla , Lenzi Andrea , Isidori Andrea , Venneri Mary Anna , Faggiano Antongiulio , Giannetta Elisa

Introduction: Immune tumor microenvironment plays a key role in tumors’ growth and metastatic spread, while its role in the heterogeneous field of neuroendocrine neoplasms (NENs) remains unclear. There is evidence that tumor progression in NENs is promoted by an immunosuppressed microenvironment created by a plethora of infiltrating immune cells. Changes in circulating leukocyte and peripheral blood mononuclear cell (PBMC) subpopulations can mirror the local alteration of...

ea0090p120 | Endocrine-related Cancer | ECE2023

Risk of Bilateral Testicular Germ cell Tumors: a single center long-term experience

Tenuta Marta , Mazzotta Paola , Sesti Franz , Angelini Francesco , Di Vito Valentina , Gelibter Alain J. , Paoli Donatella , Gianfrilli Daniele , Isidori Andrea M. , Pozza Carlotta

Background: Bilateral testicular germ cell tumors (B-TCGT) are reported as rare findings (incidence 1-8%) and can be distinguish in synchronous (sB-TCGT) (recurrence within 3 months) and metachronous (mB-TCGT) (recurrence after 3 months). Risk factors of relapse are still underexplored. The aim of our study was to identify clinical, biochemical and radiological risk factors for the onset of a second tumor in a wide cohort of TGCT patients. Materials and ...

ea0063gp2 | Adrenal and Neuroendocrine - Tumour | ECE2019

Lanreotide therapy vs wait-and-see in patients with pancreatic neuroendocrine tumors

Faggiano Antongiulio , Modica Roberta , Calzo Fabio Lo , Camera Luigi , Napolitano Vincenzo , Altieri Barbara , De Cicco Federica , Bottiglieri Filomena , Sesti Franz , Isidori Andrea M. , Colao Annamaria

Background & Aim: Pancreatic neuroendocrine tumors (pNETs) are detected in >80% of MEN1 patients. MEN1 pNETs are well differentiated G1-G2 NETs. They are usually not surged unless a size >1–2 cm or a growth rate >0.5 cm per year. Somatostatin analogues represent one of the main therapeutic option in patients affected with G1-G2 NETs. However, neither somatostatin analogues nor other therapies have been prospectively evaluated in clinical trials specificall...

ea0063p450 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Prognostic role of angiogenesis-associated factors Tie2 and Angiopoietin 2 in patients with neuroendocrine neoplasms: The NETTARE Unit experience

Puliani Giulia , Sesti Franz , Feola Tiziana , Sbardella Emilia , Cozzolino Alessia , Pofi Riccardo , Faggiano Antongiulio , Lenzi Andrea , Anastasi Emanuela , Venneri Mary A , Giannetta Elisa , Isidori Andrea M

Introduction: The role of Angiopoietin (Ang)/Tie2 kinase pathway in neuroendocrine neoplasms (NENs) has recently received increasing attention, but its clinical role remains unclear. Tie2-receptor inactivation favours chronic inflammation. The balance between its agonist and antagonist regulates its signalling. Aim of this study was to measure serum soluble Tie2 (sTie2) and Ang-2 in patients followed at the NETTARE Unit (NeuroEndocrine TAsk foRcE of ‘Sapienza’ Univer...

ea0075r07 | Reproductive Endocrinology | EYES2021

Testicular microvascular flow is altered in Klinefelter syndrome and predicts circulating testosterone: a preliminary cross-sectional study

Carlomagno Francesco , Pozza Carlotta , Tenuta Marta , Pofi Riccardo , Tarani Luigi , Mazzotta Paola , Sesti Franz , Minnetti Marianna , Gianfrilli Daniele , Isidori Andrea M.

Background: Experimental studies on Klinefelter syndrome (KS) reported increased intratesticular testosterone (T) levels coexisting with reduced circulating levels. Abnormalities in testicular microcirculation have been claimed; however, no studies investigated in vivo testicular blood flow dynamics in humans with KS.Objective: To analyze the testicular microcirculation in KS by contrast-enhanced ultrasonography (CEUS) and correlate vascular par...

ea0075d24 | Diabetes | EYES2021

Sex-specific cardioprotection of daily tadalafil in patients with type-2 diabetes. The RECOGITO, randomized, double-blind, placebo-controlled trial

Pofi Riccardo , Giannetta Elisa , Feola Tiziana , Galea Nicola , Campolo Federica , Barbagallo Federica , Badagliacca Roberto , Barbano Biagio , Ciolina Federica , Defeudis Giuseppe , Filardi Tiziana , Sesti Franz , Minnetti Marianna , Dario Vizza Carmine , Pasqualetti Patrizio , Carbone Iacopo , Francone Marco , Catalano Carlo , Pozzilli Paolo , Lenzi Andrea , Venneri Mary Anna , Gianfrilli Daniele , Isidori Andrea M.

Background: Cyclic GMP-phosphodiesterase type 5(PDE5) inhibition was shown to counteract maladaptive cardiac changes triggered by diabetes in some, but not all studies.Objective: To assess sex differences in cardiac remodeling after PDE5 inhibition in patients with diabetic cardiomyopathy.Methods: 20-week, double-blind, randomized, placebo-controlled trial (NCT01803828). 220 men and women (45-80 years) with long-duration (>3 ye...