Searchable abstracts of presentations at key conferences in endocrinology

ea0026p726 | Diabetes (epidemiology, pathophysiology) | ECE2011

Effects of the ghrelin gene products on glucose metabolism in C2C12 muscle cells

Grande Cristina , Settanni Fabio , Gesmundo Iacopo , Taliano Marina , Ghigo Ezio , Granata Riccarda

Type II diabetes is a clinical disorder of glucose and fat metabolism, caused by an inability of insulin to promote sufficient glucose uptake into adipose tissue and striated muscle and to prevent glucose output from the liver. Skeletal muscle is an important element for the maintenance of glucose homeostasis because it can increase, after stimulation, glucose uptake from the blood. In previous experiments we found that acylated ghrelin (AG), unacylated ghrelin (UAG), obestati...

ea0014oc6.1 | Cardiovascular endocrinology | ECE2007

Growth hormone-releasing hormone prevents cardiomyocyte apoptosis and activated PI3K/AKT, ERK1/2 and CREB signaling pathways

Granata Riccarda , Trovato Letizia , Destefanis Silvia , Settanni Fabio , Annunziata Marta , Gallo Davide , Ghigo Ezio

The hypothalamic hormone growth hormone-releasing hormone (GHRH), has been shown to function via its receptor splice variants as an autocrine/paracrine growth factor in normal and malignant cell lines and tissues, besides positively regulating growth hormone (GH) synthesis and secretion from the pituitary. Moreover, GHRH antagonists are known to suppress the proliferation of a wide variety of cancer cells through mechanisms yet to be fully elucidated. Aim of this study was to ...

ea0022p360 | Diabetes | ECE2010

Obestatin and ghrelin inhibit apoptosis of human pancreatic islet endothelial cells in high glucose culture

Favaro Enrica , Zanone Maria Maddalena , Miceli Ilaria , Settanni Fabio , Camussi Giovanni , Perin Paolo Cavallo , Ghigo Ezio , Granata Riccarda

Pancreatic islet microendothelium exhibits unique structural and functional features, in an interdependent physical and functional relationship with the neighbouring β-cells. Glucose toxicity is not solely restricted to β-cells, but affects also survival, proliferation of human pancreatic islet endothelial cells, thus possibly contributing to β-cell function impairment and β-cell loss. It has been previously demonstrated that the ghrelin gene derived peptid...

ea0020oc4.5 | Acromegaly/IGF1/Type 2 Diabetes | ECE2009

Regulation of obestatin levels during unacylated ghrelin infusions in normal and type 2 diabetic patients

St-Pierre David H , Settanni Fabio , Olivetti Ilaria , Gramaglia Elena , Benso Andrea , Riganti Fabrizio , Ghigo Ezio , Broglio Fabio

Background: Obestatin, a ghrelin gene product was recently isolated but important questions remain regarding its regulation and its physiological effects. The aim of the present study was to evaluate the effect of unacylated ghrelin (UAG) on obestatin levels in normal subjects and patients with type 2 diabetes (T2D).Methods: Five normal subjects and 5 T2D patients were included in this study. Unacylated ghrelin (3 μg/kg per hour) or saline were cont...

ea0016p512 | Obesity | ECE2008

No feedback inhibition of obestatin during acylated ghrelin infusion in humans

Lucatello Barbara , St-Pierre David H. , Settanni Fabio , Olivetti Ilaria , Benso Andrea , Granata Riccarda , Ghigo Ezio , Broglio Fabio

Background: Obestatin is a 27 aa peptide derived from the ghrelin gene. Obestatin was first described to exert anorexigenic effects by decreasing gastric motility in rodent models, however these results have been debated and there is presently only small information regarding its activity and its regulation in humans. Furthermore, its interactions with acylated ghrelin (AG), derived from the same gene, have not been evaluated. Therefore, in these preliminary data, we sought to...

ea0016p611 | Reproduction | ECE2008

Endometriotic cell proliferation and survival are inhibited by somatostatin analogues and GHRH antagonists

Annunziata Marta , Trovato Letizia , Settanni Fabio , Grande Cristina , Gallo Davide , Camanni Marco , Deltetto Francesco , Ghigo Ezio , Granata Riccarda

Somatostatin (SST) and growth hormone-releasing hormone (GHRH) are hypothalamic hormones that, respectively, inhibit and stimulate pituitary GH secretion. In addition, in peripheral tissues somatostatin and its analogues inhibit, whereas GHRH stimulates, both normal and cancer cell growth and survival. Furthermore, both somatostatin receptor 2 (SSTR-2) and GHRH expression have been shown in normal human endometrium. Endometriosis is a common estrogen-dependent disorder defined...

ea0063p1015 | Interdisciplinary Endocrinology 2 | ECE2019

Advanced glycation end-products and chronic inflammation in adult survivors of childhood leukemia treated with hematopoietic stem cell transplantation: possible role in the pathogenesis of cardiovascular late effects

Felicetti Francesco , Cento Alessia Sofia , Fornengo Paolo , Cassader Maurizio , Mastrocola Raffaella , D'Ascenzo Fabrizio , Settanni Fabio , Benso Andrea , Arvat Emanuela , Collino Massimo , Fagioli Franca , Aragno Manuela , Brignardello Enrico

Cardiovascular (CV) diseases significantly contribute to the mortality excess observed in survivors of pediatric acute lymphoblastic leukemia (ALL) who received hematopoietic stem cell transplantation (HSCT). The study explores advanced glycation end-products (AGEs) levels, inflammatory status and lipid profile in a cohort of ALL survivors, in order to investigate their potential role in the pathogenesis of CV late effects. Inclusion criteria were: a) previous diagnosis of ALL...

ea0070aep50 | Adrenal and Cardiovascular Endocrinology | ECE2020

Prevalence of primary aldosteronism and association with cardiovascular complications in patients with resistant and refractory hypertension

Parasiliti Caprino Mirko , Lopez Chiara , Prencipe Nunzia , Lucatello Barbara , Settanni Fabio , Giraudo Giuseppe , Rossato Denis , Benso Andrea , Ghigo Ezio , Maccario Mauro

Background: Primary aldosteronism (PA) is the most frequent form of secondary hypertension, with a high prevalence in resistant hypertension (RH), a condition of insufficient blood pressure (BP) control despite a 3-drug based treatment at full dose, including a diuretic. The prevalence of PAin refractory hypertension (ReH), a condition of persistently elevated BP values despite therapy with 5 drugs, is not known.Objective: To investigate the prevalence o...

ea0016p175 | Diabetes and cardiovascular diseases | ECE2008

Long term N-acetylcysteine and L-arginine administration reduces endothelial activation and systolic blood pressure in hypertensive patients with type 2 diabetes mellitus

Masha Andi , Gigliardi Valentina Ramella , Brocato Loredana , Manzato Enzo , Berchio Arrigo , Massarenti Paola , Settanni Fabio , Bergamini Stefania , Iannone Anna , Martina Valentino

Objective: Reactive oxygen species and nitric oxide (NO) have recently been considered involved in the cardiovascular complications of patients with type 2 diabetes as NO is supposed to loose its physiological beneficial effects, due to the presence of oxygen radicals. For this reason, we tested the effects of L-arginine (ARG) and N-acetylcisteine (NAC) administration with the aim to increase NO physiological production reducing free radical formation.</p...

ea0081rc13.7 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

An observational retrospective study on the association of urine metanephrine levels with cardiometabolic risk in patients with nonfunctioning adrenal incidentaloma

Di Carlo Maria Chiara , Parasiliti Caprino Mirko , Lopez Chiara , Bollati Martina , Bioletto Fabio , Sola Chiara , Ponzetto Federico , Gesmundo Iacopo , Settanni Fabio , Ghigo Ezio , Mengozzi Giulio , Maccario Mauro , GIORDANO Roberta

Background: Several studies argued that the cardiovascular evaluation of patients with nonfunctioning adrenal incidentaloma is of particular importance, even if a direct association seems difficult to underline.Objective: We aimed to evaluate the possibility of stratifying cardiometabolic risk through metanephrine levels in patients with incidentally discovered nonfunctioning adrenal adenoma.Design: In this retrospective cross-sect...