Endocrine Abstracts

Ipilimumab is a monoclonal antibody that had been shown significantly to improve survival in cases of metastatic melanoma. It blocks cytotoxic T-lymphocyte antigen 4(CTLA4) resulting in T-cell activation, proliferation and antitumor response. However recently an emerging clinical entities of different endocrinopathies have been reported in patients on ipilimumab. These are mainly related to lymphocytic hypophysistis causing anterior hypop...

Ipilimumab is a monoclonal antibody that had been shown significantly to improve survival in cases of metastatic melanoma. It blocks cytotoxic T-lymphocyte antigen 4(CTLA4) resulting in T-cell activation, proliferation and antitumor response. However recently an emerging clinical entities of different endocrinopathies have been reported in patients on ipilimumab. These are mainly related to lymphocytic hypophysistis causing anterior hypop...

Introduction: TSHomas are rare pituitary tumors that secrete an abnormal amount of a hormone called thyroid-stimulating hormone (TSH). Alternatively given the name thyrotropinoma, only makes up to 1%–2% of all pituitary adenomas. Patients often remain misdiagnosed for years. Many patients undergo treatments that end up destroying the thyroid gland. This case report is to emphasize the rarity of the condition and the importance of diagnosing it early and accurately to ensu...