Searchable abstracts of presentations at key conferences in endocrinology

ea0034oc2.1 | Endocrine regulation of cell behaviour | SFEBES2014

A novel modulator of cell invasion and metastasis

Watkins Rachel , Smith Vicki , Sharna Neil , Read Martin , Kwan Perkin , Fletcher Rachel , Boelaert Kristien , Franklyn Jayne , McCabe Chris

Metastasis is a multistep process responsible for the vast majority of endocrine cancer deaths. We have previously identified the proto-oncogene PBF to be upregulated in differentiated thyroid cancer, and recently PBF expression has been correlated with distant thyroid cancer metastasis at diagnosis. Further, PBF potently induces breast cancer cell invasion in vitro, and our recent in vivo data demonstrate that colorectal tumours with higher PBF protein expre...