Searchable abstracts of presentations at key conferences in endocrinology

ea0019s83 | (1) | SFEBES2009

Photoperiodic signalling in birds

Sharp P

Photoperiodic time measurement is achieved through a hypothalamic pacemaker that generates a circadian rhythm of photoinducibilty. The presence of light during the photoindicible phase of this rhythm induces photoperiodic responses. Coincidence of light and the photoinducible phase induces increased expression of TSH beta in pars tuberalis cells that results in a local increase in TSH in the adjacent medial basal hypothalamus (MBH). This in turn stimulates local ...

ea0007s50 | Molecular Endocrinology Workshop | BES2004

Mammalian RNA interference pathways

McManus M , Sharp P

Now that the sequence of the entire human genome is known and the number of predicted genes is estimated, the next challenge is to assign biological function to each of the genes. A new and very powerful way for exploring gene function is offered by RNA interference (RNAi). In this method, the introduction of double-stranded RNA identical in sequence to that of the gene of interest inactivates the gene or, more precisely, 'interferes' with its function.T...

ea0099p507 | Endocrine-Related Cancer | ECE2024

SRSF6 modulates histone-chaperone HIRA splicing to orchestrate androgen and E2F signalling in prostate cancer

Montero-Hidalgo Antonio J , Vacas Juan Manuel Jimenez , Gomez-Gomez Enrique , Blazquez-Encinas Ricardo , Sanchez-Sanchez Rafael , Martinez-Fuentes Antonio Jesus , Eyras Eduardo , Castano Justo P , Sharp Adam , Olmos David , Gahete Manuel D , Luque Raul M

Prostate cancer (PCa) is one of the most common endocrine-related cancers (ERCs) among men worldwide. The aggressiveness of this tumor pathology is highly influenced by different endocrine-related factors, highlighting the crucial role of androgens. Therefore, the main therapeutic approach for PCa patients is based on the pharmacological blockade of androgen-signaling. However, some patients become unresponsive and develop a highly lethal castration-resistant disease, pointing...