ea0031p291 | Pituitary | SFEBES2013
Mitchell R T
, Anderson R A
, van den Driesche S
, McKinnell C
, MacPherson S
, Wallace W H B
, Kelnar C J H
, Sharpe R M
Context: In rodents, in-utero exposure to the exogenous oestrogen diethylstilboestrol (DES) results in reproductive abnormalities in male offspring. It has been proposed that similar anti-androgenic effects also occur in the human fetal testis following oestrogen exposure.Objective: Determine effects of DES exposure on testosterone production by normally growing human fetal testis xenografts.Design: Human fetal testes (15&...