ea0065p347 | Reproductive Endocrinology and Biology | SFEBES2019
Ganguly Ankana
, Shattock Alexandra
, Joseph Annsha
, Gupta Janesh
, Hewison Martin
The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D) is abundant in decidua but its role in placental development is unclear. We hypothesized that decidual 1,25(OH)2D promotes placentation in early-pregnancy via actions on trophoblastic cell invasion. Using trophoblastic JEG3, BeWo and HTR8 cells we showed that 1,25(OH)2D has no effect on trophoblastic cell proliferation and migration in plasticware culture. However, in Matrigel t...