Searchable abstracts of presentations at key conferences in endocrinology

ea0021p346 | Steroids | SFEBES2009

Salivary aldosterone is a useful marker of serum aldosterone in normotensive individuals

McMurray Emily , Atkinson Brew , Mullan Karen , Cundick Jennifer , Sheridan Brian , Bell Patrick

Primary aldosteronism is an important cause of secondary hypertension though its diagnosis can prove challenging. In normal individuals aldosterone release follows a diurnal pattern, with a morning peak and low levels in the evening. Aldosterone is present in saliva and due to its lipophilic nature it passes into saliva along a concentration gradient. Salivary steroid testing is well established for cortisol and testosterone, but not yet for aldosterone....

ea0015p189 | Endocrine tumours and neoplasia | SFEBES2008

Screening for Cushing’s syndrome in the diabetic clinic using nocturnal salivary cortisol

Mullan Karen , Black Neil , Burgess Colin , Leslie Hillary , Thiraviaraj Athinia , Sheridan Brian , Atkinson Brew

Sub-clinical Cushing’s syndrome has, in recent years, been described among diabetic populations but no consensus has emerged about the value of screening. We enrolled 201 consecutive diabetics attending clinic and 80 controls. Local ethics committee approval was obtained. Patients with at least 2 of the following 3 criteria were offered screening: HbA1c≥7%, BMI≥25 and history of hypertension or BP≥140/90. An 11 pm salivary sample was stored at room tempe...

ea0013p31 | Clinical practice/governance and case reports | SFEBES2007

The assessment of growth hormone deficiency following pituitary surgery – a need for greater awareness

Lewis Anthony , Courtney Hamish , Hunter Steven , McCance David , Sheridan Brian , Atkinson Brew

Pituitary surgery frequently leads to one or more anterior pituitary hormone deficiencies but the incidence of GH deficiency is unclear. The aim of our study was to establish the incidence of GH deficiency in patients post hypophysectomy. Current NICE guidelines recommend GH replacement in severely GH deficient patients who have one or more other pituitary hormone deficiencies and diminished QoL by AGHDA.Thirty-five patients (M:F 15:20; age range 23&#150...

ea0021p295 | Pituitary | SFEBES2009

Effects on insulin action of dehydroepiandrosterone sulphate replacement in hypopituitary females

McHenry Claire , Bell Patrick , Hunter Steven , Thompson Christopher , Courtney Hamish , Ennis Cieran , Sheridan Brian , McCance David , Mullan Karen , Atkinson Brew

Hypopituitary patients are at increased vascular risk. This may be partly attributable to changes in insulin action. It has been suggested that the addition of dehydroepiandrosterone sulphate (DHEAS), which is low in patients with secondary hypoadrenalism, to routine replacement may have beneficial effects on glucose metabolism. Previously, patient populations and techniques used to assess insulin action varied and overall results have been conflicting.W...