Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1217 | Obesity | ICEECE2012

Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in chinese young adults

Shi J. , Hong J. , Gu W. , Zhang Y. , Cui B. , Yan Q. , Wang W. , Ning G.

Clear evidence on the specific impact of fatty acid binding proteins (FABPs) on cell biology and lipid metabolism in complex systems had been lacking until FABP-deficient mice models were created. Surprisingly, no change in appearance, gross morphology or viability was observed in FABP1-deficient mice. However, metabolic parameters in mice upon exposure to high-fat/cholesterol diet differed between studies. Therefore, liver fatty acid-binding protein (also called FABP1) plays ...

ea0029oc12.4 | Obesity Clinical | ICEECE2012

Genetic susceptibility, birth weight and obesity risk in young chinese

Shi J. , Hong J. , Qi L. , Cui B. , Gu W. , Zhang Y. , Li L. , Xu M. , Wang L. , Zhai Y. , Miao L. , Wang R. , Bi Y. , Wang W. , Ning G.

Thus far, approximately 30 loci influencing body mass index (BMI) and the risk of obesity have been identified. In this study, we aimed to examine the individual and joint associations of 23 BMI-associated loci identified from recent genome-wide association studies in Caucasians with obesity risk in young Chinese. Birth weight reflects prenatal metabolic adaption and has been related to later-life obesity risk. We particularly assessed whether these genetic variants interacted...