Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep82 | Calcium and Bone | ECE2021

Correlation between parathyroid adenoma volume and markers of calcium-phosphate metabolism in patients with primary hyperparathyroidism

Yankova Inna , Ivanova Gergana , Shinkov Alexander , Kovatcheva Roussanka

IntroductionIn primary hyperparathyroidism (PHPT) the chronic overproduction of parathormone (PTH) is mostly due to a solitary adenoma.AimThe aim of our study was to examine the relationship between calcium-phosphate metabolism and the volume of the parathyroid adenoma (PTA) in patients with PHPT.Material and methodsThe study included 195 patients with biochemical...

ea0073aep663 | Thyroid | ECE2021

Thyroid-receptor antibodies, immunoglubulin E and antinuclear antibodies in patients with Graves’ disease and their association with Graves’ orbitopathy and smoking habits

Stoynova Mariya , Shinkov Alexander , Kirilov Georgi , Kovatcheva Roussanka

IntroductionThyrotropin-receptor antibodies (TRAb) play a key role in the pathogenesis of Graves’ disease (GD) and Graves’ orbitopathy (GO) and are important for the diagnosis of both diseases. Elevated levels of immunoglobulin E (IgE) and antinuclear antibodies (ANA) were also found in GD patients. Smoking is a risk factor for GD and GO development and GO progression. We aimed to assess the associations between TRAb, IgE and ANA, and the prese...

ea0041ep1039 | Thyroid (non-cancer) | ECE2016

Comparison of thyroid nodule prevalence in two population-based studies in Bulgaria: 2006 and 2012

Shinkov Alexander , Borissova Anna-Maria , Kovatcheva Roussanka , Dakovska Lilia , Vlahov Jordan , Vukov Mirtcho

The nodular goiter is the most prevalent thyroid disorder. Its prevalence increases with age and reaches over 70%. The aim of the study was to compare the nodule prevalence in two population-based studies, carried in Bulgaria in 2006 and 2012.Material and methods: Two thousand four hundred and two subjects (1347 female and 1053 male, age range 20–94 years) were included in 2006 and 2022 (1073 female and 949 male, 20–88 years) in 2012. All subje...

ea0035p939 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Individual risk factors of metabolic syndrome in adult patients with GH deficiency: a cross-sectional case-control study

Uzunova Ivayla , Kirilov Georgi , Zacharieva Sabina , Shinkov Alexander , Borissova Anna-Maria , Kalinov Krassimir

Metabolic abnormalities in adult GH deficiency (AGHD) determine its significance as a disease associated with increased cardiovascular risk. However, recent contradictory data about the long-term beneficial effects of GH replacement, especially on cardiovascular risk, provoked some further analysis of its contributory factors.Aim of the study: To identify the individual risk factors of metabolic syndrome (MS) in AGHD and to compare the prevalence and the...

ea0022p864 | Thyroid | ECE2010

HOMA index and waist circumference do not correlate with TSH levels in a group of euthyroid adults

Shinkov Alexander , Borissova Anna-Maria , Atanassova Iliana , Kovatcheva Roussanka , Vlahov Jordan , Aslanova Nina

The aim of the study was to investigate the relationship among the indices of insulin resistance (IR), the lipid parameters and thyroid function in euthyroid adults.Material and methods: Two hundred and sixteen euthyroid adults, mean age 57.08±13.81 years (112 female and 104 male) were included. Serum lipirds, Immunoreactive insulin, glucose, TSH, waist circumference (WC), body height and weight were measured. HOMAi and BMI were calculated.<p cl...

ea0073aep666 | Thyroid | ECE2021

Increased gene expression of TIMP1 and CHI3L1 in fine-needle aspiration biopsy washouts from papillary thyroid cancer

Dimitrova Inna , Shinkov Alexander , Dodova Rumyana , Ivanova Radina , Kaneva Radka , Kovatcheva Roussanka

AimTo assess the relative expression of tissue inhibitor of metalloproteinase-1 gene (TIMP1) and chitinase-3-like protein 1 gene (CHI3L1) in fine-needle aspiration biopsy (FNAB) washouts and the serum levels of their protein products (TIMP-1 and chitinase-3-like protein 1 also known as YKL-40) in patients with histologically confirmed papillary thyroid cancer (PTC) and with benign nodules. Further, we evaluated the correlation between the gene expression...