Endocrine Abstracts

Type 1 diabetes mellitus (T1D) is caused by a process of altered humoral and cellular immunity, resulting in the destruction of insulin-producing cells. VD(25(OH)D3) insufficiency is implied as risk factor for T1D, while VD substitution in infantry is associated with a reduced T1D incidence. In T1D daily insulin injection is required for a stable glucose homeostasis and insulin demand rises by a higher Body Mass Index (BMI). Today there are no studies investigating ...

Dysregulated T helper cells and vitamin D (VD) deficiency are important factors in the pathogenesis of Type 1 diabetes mellitus (T1D). Therefore, we investigated the immune effects of high dose VD-treatment on gene expression (GE) pattern in T helper cells (Th) before and after VD-therapy in patients with T1D.Methods: Seven T1D patients with 25(OH)D3 levels below 20 ng/ml received 3 months 4000 IU/d Vigantol oil. The 25(OH)D3 plasma...