Searchable abstracts of presentations at key conferences in endocrinology

ea0038p35 | Clinical biochemistry | SFEBES2015

Biochemical evaluation of adrenal incidentalomas referred to endocrine surgery in a large teaching hospital

Davison Andrew , Hill Charlotte , Russell Nicki , Waghorn Alison , Shore Susannah

Background: Adrenal incidentaloma (AI) increasingly pose a diagnostic challenge. This retrospective observational study evaluated biochemical investigations performed in patients referred to Endocrine Surgery with AI and assessed adherence to Guidelines. Biochemical, histological and radiological characteristics of AI were also reviewed.Methods: Data were collected from Hospital and Laboratory records for referrals between January 2012┬ľApril 2014.</...

ea0034p339 | Reproduction | SFEBES2014

Hyperandrogenism secondary to ovarian hyperthecosis masked by concurrent use of an aromatase inhibitor: a case report

Khan Muhammad , Ahluwalia Rupa , Shore Susannah , Waghorn Alison , Vora Jiten

Backgound: We report a case of a 63-year-old postmenopausal female diagnosed with ovarian hyperthecosis masked by concurrent use of an aromatase inhibitor.Following diagnosis of breast cancer in 2009, requiring mastectomy with adjunctive chemotherapy, she was commenced on anastrozole. Later she noted gradual onset of frontal balding and hirsutism. Biochemistry revealed elevated serum levels of testosterone 13.2 nmol/l (range: <1.9 nmol/l) and androst...

ea0077p141 | Adrenal and Cardiovascular | SFEBES2021

Auditing Adrenal Vein Sampling for Primary Aldosteronism to highlight existing challenges

Davies Sarah , Parvulescu Flavius , Evans Jonathan , Waghorn Alison , Shore Susannah , Davison Andrew

Introduction: Clinical Practice Guidelines1 advocate adrenal vein sampling (AVS) to distinguish between unilateral and bilateral primary aldosteronism (PA). Cannulating the right adrenal vein is difficult, and there is a lack of standardisation in sampling procedure and interpretation2. We audited our local service to identify improvements.Methods: All AVS procedures performed between January 2018-December 2020 (n = 31) wer...

ea0081p553 | Calcium and Bone | ECE2022

Case report: an unusual presentation of hypercalcaemia in pregnancy

Williams Scott , Kejem Helmine , Wynne Sian , Nizza Jael , Tildesley Rachel , Shore Susannah , Lim Rebecca

A 26-year-old Caucasian female presented at 14 weeks gestation with a 6-week history of lethargy, nausea and vomiting during her first pregnancy. Her adjusted Calcium was 4.12 mmol/l and parathyroid hormone (PTH) 26 pmol/l, consistent with possible primary hyperparathyroidism. She was previously well apart from occasional migraines. There was no known history of familial hypercalcaemia or MEN. Other biochemistry results revealed hypokalaemia of 3.2 mmol/l, low vitamin D at 16 ...

ea00100oc9 | Oral Communications | SFEEU2024

Mediastinal ectopic parathyroid in pregnancy

Kattakayam Freddy , Tildesley Rachel , Wynne Sian , Lim Rebecca , Woolley Steven , Shore Susannah

A 26-year-old primigravida woman presented with hypercalcaemia at 8-weeks gestation. Initial symptoms included nausea, vomiting and palpitations, with an admission serum adjusted calcium of 3.8 mmol/l. A biochemical diagnosis of primary hyperparathyroidism (PHPT) was supported by a raised PTH and a 24-hour urinary calcium-creatinine ratio of 2.0 mmol/ mmol, excluding familial hypocalciuric hypercalcaemia. Initial management with intravenous fluids and antiemetics was unable to...

ea0077oc4.3 | Adrenal and Cardiovascular | SFEBES2021

[11C]Metomidate PET/CT can aid decision-making in patients with primary aldosteronism

Senanayake Russell , Gillett Daniel , Ali Zahabia , Bashari Waiel , MacFarlane James , Koulouri Olympia , van der Meulen Merel , Powlson Andrew , Challis Benjamin , Palma August , Hu Lihua , Aloj Luigi , Mendichovszky Iosif , Cuthbertson Dan , Shore Susannah , Levy Miles , Drake William , Brown Morris , Kosmoliaptsis Vasilis , Marker Alison , Cheow Heok , Gurnell Mark

Background: Primary aldosteronism (PA) is the leading, potentially reversible, cause of secondary hypertension. For most patients in whom surgery is being considered, adrenal vein sampling (AVS) is recommended to distinguish unilateral and bilateral causes. However, AVS remains technically challenging, and a significant proportion of patients are unable to progress to surgery because AVS is unavailable or unsuccessful. We have explored whether [11C]Metomidate PET/CT...