ea0077p243 | Reproductive Endocrinology | SFEBES2021
Shrewsbury Jed V
, Ng Kah-Yan
, McIntyre Caitlin
, Li Xiao Feng
, Phylactou Maria
, O’Byrne Kevin T
, Abbara Ali
, Dhillo Waljit S
, Owen Bryn M
Kisspeptin is integral to hypothalamo-pituitary-gonadal (HPG) axis function and overall fertility. Functional deficiency of GnRH/lH secretion in the central reproductive disease, hypothalamic amenorrhoea (HA), indicates diminished kisspeptin signalling. Clinical trials have shown kisspeptin to be a viable therapeutic intervention. However, repeated administration led to the development of tachyphylaxis and so is likely a problem for future implementation. Indeed, elevated LH r...