Endocrine Abstracts

Introduction: SARS-COV-2 is a new infection with little known consequences. As data accumulated, it became known that the thyroid gland is also affected as a result of infection. During the reconvalescence period, some patients developed severe thyrotoxicosis, which did not have the classic clinical picture of subacute thyroiditis or autoimmune.Aim: To study the course of subacute thyroiditis in patients after infection with COVID-19.<p class="abstex...

The article is devoted to one of the most pressing medical problems – diabetes mellitus type 2.Objective: To study the peculiarities of the course of diabetes mellitus type 2 in persons over 65 years of age; to evaluate the effectiveness of different therapy regimens for the level of HbA1C.Material and methods: The retrospective study included 100 patients with type 2 diabetes (T2D). The age of the patients: 65 to 82 years. Th...

Introduction: Glutathione system prevents oxidative stress development in erythrocites. When this system becomes depressed it predisposes a cell to apoptosis.Aim: To study glutathione system status in patients with diabetesMaterials and methods: Included patients were divided into four groups: group 1–41 almost healthy person (control group), group 2–41 patients with type 2 diabetes (T2D), group 3–40 patients with T2...

Introduction: Glutathione system prevents oxidative stress development in erythrocites. When this system becomes depressed it predisposes a cell to apoptosis.Aim: To study glutathione system status in patients with diabetesMaterials and methods: Included patients were divided into four groups: group 1–41 almost healthy person (control group), group 2–41 patients with type 2 diabetes (T2D), group 3–40 patients with T2...

It is known that presence of certain genetic polymorphism plays important role in development of chronic complications in patients with type 2 diabetes (T2D).Aim: To analyze distribution of VEGF G/C polymorphisms and PAI-1 4G/5G polymorphisms in patients with T2D and IHD.Materials and methods: The following groups of studies were formed: 1 – 24 almost healthy people; 2 – 28 patients with prediabetes; 3 – 37 patients ...

Neutrophil gelatinase-associated lipocalin (NGAL) was shown to be highly useful in assessing kidney injury in patients with diabetic nephropathy. Taking into account recent data that dysthyroidism may have reversible effects on GFR the purpose of the study was to investigate potential relationship between serum NGAL levels, thyroid status and ultrasound thyroid characteristics in patients with type 1 diabetes (T1D) with CKD.Materials and methods: We recr...

Neutrophil gelatinase-associated lipocalin (NGAL) was shown to be highly useful in assessing kidney injury in patients with diabetic nephropathy. Taking into account recent data that dysthyroidism may have reversible effects on GFR the purpose of the study was to investigate potential relationship between serum NGAL levels, thyroid status and ultrasound thyroid characteristics in patients with type 1 diabetes (T1D) with CKD.Materials and methods: We recr...

Rationale: Obesity, prediabetes and diabetes are strongly associated with microcirculation (MC) abnormalities. It is known that pathological changes in microvessels predispose to CHD, CKD and retinopathy. Also it is widely recognized that biochemical and immunological changes accompanied with obesity and overweight lead to MC damage.ObjectiveOf the study was to assess changes in MC in patients with overweight and obesity.<p cla...

Background: Plasminogen activator inhibitor-1 (PAI-1) refers to group of is a serine protein inhibitors. It inhibits fibrinolysis and contributes to angiogenesis and atherogenesis processes. 4G/5G polymorphism was found to be associated with increased risk for cardiovascular diseases. It was of special interest to study PAI-1 polymorphism in patients with diabetes.Aim: Aim to study PAI-1 polymorphism in patients with type 2 diabetes (T2D) and concomitant...

Background: Diabetic nephropathy (DN) is a major cause of morbidity and mortality in type 1 diabetes (T1D) patients and associated with increased cardiovascular risk in type 2 diabetes (T2D) patients. Early detection of DN using neutrophil gelatinase-associated lipocalin (NGAL) assessment can help to reveal predisposed patients to its progression and to prevent progression of DN. Especially important it is in patients with normoalbuminuria.Aim: To determ...