Searchable abstracts of presentations at key conferences in endocrinology

ea0101op-04-03 | Oral Session 4: Young Investigators/Basic | ETA2024

The role of type 3 deiodinase in a human model for early brain development

Lopez Marti Anna , Gunhanlar Nilhan , Sidal Gunduz Damla , Stavast Christiaan , Meima Marcel , Edward Visser W.

Background: Disrupted thyroid hormone (TH) homeostasis has devastating effects on human neurodevelopment. THs are critical signaling molecules in neurodevelopment, acting on differentiation of neural cells, migration, synaptogenesis and myelination, with deiodinases governing intracellular TH concentrations in a spatiotemporal manner. It is remarkable that fetal neural cells, while being key target cells of TH, exhibit strong activity of the TH inactivating enzyme DIO3. Curren...