Searchable abstracts of presentations at key conferences in endocrinology

ea0032p981 | Thyroid (non-cancer) | ECE2013

The influence of single dose recombinant human thyroid-stimulating hormone on the efficacy of radioiodine therapy in patients with non toxic nodular goitre with low RAIU

Abdelrazek Saeid , Mysliwiec Janusz , Szumowski Piotr , Mojsak Malgorzata , Siewko katarzyna , Poplawska-Kita Anna

Aim: The aim of our study was to evaluate the influence of recombinant human thyroid-stimulating hormone (rhTSH) on the efficacy of radioiodine therapy in patients with non toxic nodular goitre with low RAIU.Materials and methods: The study was performed on 50 patients with non toxic nodular goitre (36 females and 14 males, aged 34–75 years) referred for radioiodine therapy. All patients had low RAIU (8–16%), 24 h after a diagnostic dose of I-1...

ea0022p863 | Thyroid | ECE2010

The influence of radioiodine therapy in patient with non-toxic goiter with low RAIU in the enlarged nodule: a case report

Abdelrazek Saeid , Rogowski Franciszek , Parfienczyk Adam , Frackiel Malgorzata , Szelachowska Malgorzata , Siewko Katarzyna

A young woman aged 23 years, with non-toxic goiter was treated in our Department. Serum levels of FT4, FT3 and TSH were within normal range, high resolution ultrasonography show very large glands (60 ml), with large nodule in left lobe and smaller one in the right lobe. Malignancy was ruled out by ultrasound-guided fine-needle aspiration biopsy. Thyroid radioiodine scintigraphy showed homogenous and diffuse uptake in the right lobe, with very low uptake i...

ea0020p121 | Thyroid | ECE2009

The incidence of thyroid cancer in the North-Eastern Region of Poland: a twelve year follow-up

Zonenberg Anna , Telejko Beata , Nikolajuk Agnieszka , Siewko Katarzyna , Zimnoch Lech , Dadan Jacek , Kinalska Ida , Gorska Maria

Before the introduction of mandatory salt iodination in 1997 the North-Eastern Region of Poland was known to be a moderate iodine deficiency area. It was also exposed to ionizing radiation after the Chernobyl accident in 1986. The aim of the present study was to evaluate the descriptive epidemiological features of incident thyroid cancers diagnosed among the residents of this area between 1996 and 2007. The Regional Cancer Surveillance Program was used to collect data on 834 n...

ea0041gp200 | Thyroid - Translational & Clinical | ECE2016

Betatrophin level in Hashimoto thyreoiditis

Poplawska-Kita Anna , Siewko Katarzyna , Kosciuszko-Zdrodowska Maria , Lipinska Danuta , Milewski Robert , Poplawski Lukasz , Szelachowska Malgorzata , Gorska Maria

Aim: Clinical studies in Hashimoto thyroditis (HT) confirm, that even a minor thyroid dysfunction is related to significant changes in body mass. Betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, is a novel protein predominantly expressed in human liver and adipose tissue. Stimulators of betatrophin, such as thyroid hormones are usually relevant to energy expenditure or thermogenesis. The mechanisms of action of betatrophin are still unknown. In the present study ...

ea0041ep406 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Decreasing betatrophin levels during pregnancy in healthy women

Zielinska Anna , Maciulewski Rafal , Siewko Katarzyna , Poplawska-Kita Anna , Kozlowska Gabryela , Lipinska Danuta , Gorska Maria , Szelachowska Malgorzata

Introduction and aims: To date we have had some evidence that betatrophin is associated with insulin resistance. Some studies have demonstrated that betatrophin levels are elevated in type 2 diabetes, obesity and gestational diabetes. It has been shown that in mice betatrophin significantly improves beta cell function and glucose tolerance. This is the first study on betatrophin in which pregnant women were observed during all trimesters and in postpartum period to evaluate it...

ea0041ep463 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Interleukin-6, interleukin-15 concentrations and insulin resistance in autoimmune diabetes

Siewko Katarzyna , Zielinska Anna , Maciulewski Rafal , Poplawska-Kita Anna , Telejko Beata , Lipinska Danuta , Gorska Maria , Szelachowska Malgorzata

Background: Interleukin-15 and -6 play a role in an inflammation, autoimmune, infectious and cancerous processes. Their increased concentrations were observed in psoriasis, asthma, multiple sclerosis and type 2 diabetes. However, the role of IL-15 and IL-6 in autoimmune diabetes (AD) pathogenesis is still unknown.Aim: The aim of our study was to assay circulating IL-15 and IL-6 levels in newly diagnosed AD patients, their I° relatives and healthy co...

ea0041ep996 | Thyroid (non-cancer) | ECE2016

Transforming growth factor β1 in postpartum thyroiditis

Zielinska Anna , Maciulewski Rafal , Siewko Katarzyna , Poplawska-Kita Anna , Kozlowska Gabryela , Lipinska Danuta , Gorska Maria , Szelachowska Malgorzata

Introduction and aims: TGF-β1 participates in the pathogenesis of autoimmune diseases e.g. diabetes, Hashimoto disease, autoimmune digestive system disorders. The aim of our study was to evaluate TGF-β1 levels during pregnancy and after childbirth in women who developed postpartum thyroiditis (PPT) in comparison to the healthy control group (CG) and women with positive anti-thyroid antibodies (ATA+) who did not develop PPT.Material and method: ...

ea0037gp.26.02 | Thyroid – hypothyroidism | ECE2015

High serum IgG4 concentrations in patients with Hashimoto's thyroiditis

Poplawska-Kita Anna , Kosciuszko-Zdrodowska Maria , Siewko Katarzyna , Telejko Beata , Hryniewicka Justyna , Milewski Robert , Szelachowska Malgorzata , Gorska Maria

Purpose: Recent reports strongly suggest that at least some cases of Hashimoto’s thyroiditis (HT) may be closely associated with IgG4-related disease. In the present study we aimed to find out, whether the measurement of serum IgG4 allows for an identification of distinct types of HT, with different clinical, sonographic and serologic characteristics.Methods: The group studied consisted of 53 patients with HT and 28 healthy individuals. All the part...

ea0035p367 | Diabetes (epidemiology, pathophysiology) | ECE2014

Serum cytokines and proinflammatory markers in first degree relatives of patients with type 1 diabetes

Szelachowska Malgorzata , Siewko Katarzyna , Poplawska-Kita Anna , Telejko Beata , Zielinska Anna , Maciulewski Rafal , Lipinska Danuta , Gorska Maria

Background and aims: In patients with type 2 diabetes, elevated tumor necrosis factor α (TNFα), C-reactive protein (CRP), chemerin, fetuin-A, have been reported. However, it is not entirely clear whether these alterations in adipokine serum concentrations are already present in prediabetic states and in type 1 diabetes. The aim of the study was to investigate whether adipokine profiles (chemerin, fetuin-A, TNFα) and inflammatory markers (CRP) are associated with...

ea0035p368 | Diabetes (epidemiology, pathophysiology) | ECE2014

Increased prevalence of anti-thyroid and anti-gastric parietal cell antibodies in first degree relatives of patients with type 1 diabetes

Siewko Katarzyna , Poplawska-Kita Anna , Telejko Beata , Maciulewski Rafal , Zielinska Anna , Lipinska Danuta , Gorska Maria , Szelachowska Malgorzata

Aim: It is well known that T1D is associated with other autoimmune diseases. The aim of this study was to compare the prevalence of various auto-antibodies in first-degree relatives of patients with T1D and healthy individuals with negative family history of diabetes.Material and methods: The group studied consisted of 90 relatives and 60 healthy individuals. Serum concentrations of antibodies to anti-21-hydroxylase (21-OH-Abs), anti-gastric parietal cel...