Searchable abstracts of presentations at key conferences in endocrinology

ea0014p64 | (1) | ECE2007

Liquorice in moderate doses decreases serum levels of vitamin B12 but does not affect the serum lipid levels

Sigurjonsdottir Helga , Arnadottir Margret , Wallerstedt Sven

Background: Liquorice in moderate doses increases blood pressure (BP) in healthy individuals (NT) as well as patients with hypertension (HT) due to increased cortisol effect. Glycyrrhetinic acid, the active substance in liquorice, inhibits 11beta-hydroxysteroid-dehydrogenase type 2 (11betaHSD2) which converts the active hormone cortisol to the inactive hormone cortisone. Recently it has been reported that treatment with glucocorticoids decreases serum levels of cobalamin (B12)...

ea0081p278 | Adrenal and Cardiovascular Endocrinology | ECE2022

Success rate of adrenal venous sampling in iceland

Gunnarsdottir Hrafnhildur , Gudmundsson Jon , Birgisson Gudjon , Agusta Sigurjonsdottir Helga

Introduction: Primary aldosteronism is an important cause of hypertension. Adrenal venous sampling (AVS) is the gold-standard investigation to determine whether one or both adrenal glands are affected. AVS is a complicated procedure with success rate varying greatly from one hospital to another.Aims: To investigate the success rate of AVS at Landspitali over a 10-year period and compare it to published results from other hospitals....

ea0049ep19 | Adrenal cortex (to include Cushing's) | ECE2017

Specificity of the posture test for subtyping of primary aldosteronism, a 10 year nationwide summary in Iceland

Gunnarsdottir Hrafnhildur , Jonsdottir Gudbjorg , Gudmundsson Jon , Birgisson Gudjon , Sigurjonsdottir Helga

Introduction: The posture test (PT), developed to distinguish idiopathic adrenal hyperplasia (IAH) from aldosterone producing adenoma (APA), has been postulated as inaccurate. In 2007, standardized diagnostic methods, including PT for subclassification, were introduced in Landspitali University Hospital (LUH), housing the only endocrine department in Iceland. The aim of this study is to review the results of PT performed in LUH in 2007–2016.Methods:...

ea0049ep21 | Adrenal cortex (to include Cushing's) | ECE2017

Primary Aldosteronism in Iceland, nationwide results from 2012–2016

Gunnarsdottir Hrafnhildur , Gudmundsson Jon , Birgisson Gudjon , Sigurjonsdottir Helga

Introduction: Primary aldosteronism (PA) is an important, potentially curable cause of hypertension (HT) with higher risk of cardiovascular events than essential HT. In 2007, a standardized PA work-up protocol was introduced in Landspitali University Hospital (LUH), housing the only endocrine department in Iceland. The aim of this study is to review characteristics, test results and histopathology for patients diagnosed with PA in 2012-2016 in LUH.Method...

ea0035p1072 | Thyroid (non-cancer) | ECE2014

Antiepileptic drugs and the thyroid hormone axis

Einarsdottir Margret Jona , Olafsson Elias , Sigurjonsdottir Helga Agusta

Introduction: Antiepileptic drugs may cause altered thyroid function in adults according to previous studies. The cllinical impact of this is unclear. The aim of this study was to evaluate thyroid function in patients taking antiepileptic drugs to evaluate a possible clinical impact.Methods: Adult epileptic patients (older than 18 years old) who attended the neurology outpatient clinic at Landspitali University Hospital in Iceland (the only University Ho...

ea0070ep5 | Adrenal and Cardiovascular Endocrinology | ECE2020

The effectiveness of treatment for primary aldosteronism in Iceland 2007–2016

Gunnarsdottir Hrafnhildur , Jonsdottir Gudbjorg , Birgisson Gudjon , Sigurjonsdottir Helga

Introduction: Primary aldosteronism (PA) is a potentially curable cause of hypertension. In 2007, a standardized PA work-up protocol was introduced in Landspitali University Hospital (LUH), a tertiary care center for Iceland. The aim of this study is to review treatment response for patients diagnosed with unilateral and bilateral PA in LUH 2007–2016.Methods: All charts for PA-patients aged ≥18, diagnosed 2007–2016 in LUH, were retrospe...

ea0032p37 | Adrenal cortex | ECE2013

Adrenal venous sampling is mandatory and CT scan is unreliable for diagnosing unilateral primary hyperaldosteronism

Jonsdottir Guobjorg , Guomundsson Jon , Birgisson Gudjon , Agusta Sigurjonsdottir Helga

Introduction: There is ongoing debate about how to diagnose and treat unilateral primary hyperaldosteronism (PA). The use of CT scans and adrenal venous sampling (AVS) for the diagnosis of unilateral PA leading to unilateral adrenalectomy is still a matter of discussion. Moreover, some have suggested subtotal adrenalectomy when a detectable nodule is found on imaging studies while others prefer total adrenalectomy. We gathered information on imaging, diagnosis and treatment in...

ea0014p63 | (1) | ECE2007

Does screening of primary hyperaldosteronism only lead to diagnosis of more adrenal hyperplasia?

Sigurjonsdottir Helga , Gronowitz Mikael , Anderson Ove , Eggertsen Robert , Herlitz Hans , Johannsson Gudmundur

Background: The prevalence of primary hyperaldosteronism (PA) has recently been reported as high as 7.5% in patients with hypertension from unselected populations (USP) and up to 22% in selected populations (SP). Whether increased screening and diagnosis of PA will lead to more findings of curable PA (aldosterone producing adenoma, APA) is unclear.Methods: Three-hundred fifty-three consecutive patients with hypertension, age 20 to 88 years were included ...

ea0056gp28 | Adrenal clinical | ECE2018

Immunohistochemical staining for histopathological subclassification of primary aldosteronism: nationwide 10-year results from Iceland

Gunnarsdottir Hrafnhildur , Agnarsson Bjarni A , Jonasdottir Sigurros , Birgisson Guojon , Sigurjonsdottir Helga Agusta

Introduction: Primary aldosteronism (PA) is an important cause of hypertension. Adrenal hyperplasia (AH) and aldosterone-producing adrenocortical adenoma (APA) are considered the most frequent causes of PA. Histopathological analysis of unilateral PA has been difficult since no clear morphological criteria existed for defining aldosterone-producing cells. Recently, the distribution of adrenal cells forming aldosterone and cortisol has been studied by using specific monoclonal ...