Searchable abstracts of presentations at key conferences in endocrinology

ea0094s4.1 | Hacking the reproductive clock | SFEBES2023

Ageing and sperm health

Martins da Silva Sarah

Ageing is an inevitable biological process that affects all aspects of human physiology including reproductive health. While much attention has been devoted to the age-related decline in female fertility, the impact of ageing on male reproduction is perhaps less well appreciated. This presentation aims to provide a concise overview of the relationship between ageing and sperm health, highlighting key findings and implications. Ageing has a significant impact on sperm health an...

ea0028p10 | Bone | SFEBES2012

The use of teriparatide to treat hypoparathyroidism following thyroidectomy; a case report

De Silva Akila , De Silva Sarah-Jane , Meeran Karim

A 27 year old lady with Graves’ thyrotoxicosis (fT4 50.3 pmol/L, fT3 25.0 pmol/L, TSH<0.05 mU/L) failed to respond adequately to carbimazole (40 mg BD) or propylthiouracil (250 mg QDS). Three months later, following 10 days of potassium iodide to render her biochemically euthyroid, she underwent a total thyroidectomy. Pre-operative bone profile revealed Ca(c) 2.34 mmol/L (NR 2.15–2.60 mmol/L), phosphate 1.36 mmol/L (NR 0.8–1.4 mmol/L), PTH 3.4 pmol/L (NR 1.1...

ea0099ep198 | Thyroid | ECE2024

Gynecomastia as the first manifestation of thyrotoxicosis: an unusual case report

Cidade-Rodrigues Catarina , Benido Silva Vania , Silva Bruna , Almeida Margarida

Introduction: Gynecomastia is a benign excessive proliferation of glandular tissue in the male breast and results from an increased breast estrogen/androgen activity ratio. It may be physiological (infancy, puberty or aging) or pathological. The most common cause is drug-induced. Although hyperthyroidism is a rare cause(1.5%), gynecomastia occurs in up to 25-40% of males with Graves’ disease and is often undiagnosed. Its development as the first manifestation of this thyr...

ea0030p66 | (1) | BSPED2012

A case of GH deficiency?

de Silva Chamaleeni , Shaw Nick

Case report: A 7-year-old girl presented with short stature following removal to the UK from China, where she had been diagnosed with GH deficiency on blood testing, for which GH treatment had been recommended. She had reportedly not grown well over the previous 2 years, and though the oldest in her class, she was the smallest. She had a poor appetite but otherwise was well. She had no constipation, normal activity levels, and was doing well in school. She was born at term wei...

ea0020p287 | Clinical case reports and clinical reports | ECE2009

Progression of endocrine hypofunction: a case of polyglandular autoimmune syndrome type 2

Ratnasabapathy Risheka , De Silva Akila

A 52-year-old, previously well Indian lady was admitted in May 2008 with pneumonia. Concurrently, she was diagnosed with diabetes mellitus (blood glucose 20 mmol/l). Her BMI was 19 kg/m2 and she was initially commenced onto sulphonylurea therapy. She had a further admission in July 2008 with dizzy episodes, falls, postural hypotension (systolic postural drop 75 mmHg) and erratic blood glucose levels (range 1.1–30 mmol/l). Blood ketones were 3.6 mmol/l without a...

ea0056p432 | Diabetes complications | ECE2018

Association of adverse pregnancy outcomes with glycemic cut-offs stated by the IADPSG, POGS and WHO diagnostic criteria for gestational diabetes mellitus in De La Salle University Medical Center (DLSUMC), Cavite, Philippines from January 2012 to December 2015

Francisco Danica , Andag-Silva Aimee

Objectives: To determine the association between adverse pregnancy outcomes with each of the 75 g OGTT cut-off values prescribed by the World Health Organization (WHO), Philippine Obstetrical and Gynecological Society (POGS), and the International Association of Diabetes in Pregnancy Study group (IASDPG) criteria to help define more appropriate glycemic cut-off levels for Filipinas.Methodology: Retrospective Cohort study of pregnancy deliveries in De La ...

ea0084op-10-50 | Oral Session 10: Young Investigators / Clinical and Translational | ETA2022

Outcomes of lenvatinib therapy in poorly differentiated thyroid carcinoma

Roque Joao , Silva Tiago , Leite Valeriano

Introduction and objectives: Poorly differentiated thyroid carcinoma (PDTC) is a rare but aggressive thyroid tumor. PDTC frequently presents in advanced stages and conventional treatments are usually less effective than in differentiated thyroid carcinoma (DTC). Lenvatinib is a multi-kinase inhibitor approved for the treatment of radioiodine-refractory DTC, with significant improvement in progression free survival. Despite the inclusion of a minority PDTC patients in SELECT tr...

ea0085nep1.1 | Endocrine Symposium 3 | BSPED2022

CAH & adolescent gynaecology – an MDT perspective

Learner Hazel , Da Silva Philomena , Williams Louise

We work in a service at UCLH in London which cares for young people and adults with differences of sex development. Among other diagnoses CAH makes up quite a lot of our cohort of patients. Adolescents with CAH that our team see include those born with atypical genitalia who may have had, or have not had surgery in childhood on their clitoris or vagina. We also see adolescents with CAH who have issues with puberty and their periods. For adolescents with issues with their genit...

ea0039ep50 | Diabetes | BSPED2015

Monitoring HbA1C in patients on continuous subcutaneous insulin infusion for the treatment of type 1 diabetes

Kayello Giedre , De Silva Prasadi , Oso Olumuyiwa

AbstractContinuous subcutaneous insulin infusion (insulin pump therapy) is recommended as a treatment option for patients with type 1 diabetes where multiple-dose insulin therapy has failed. These patients are looked after by a specialist multi-disciplinary team and those receiving this treatment should have the commitment and competence to use the pump effectively.We carried out a retrospective study on 33 paediat...

ea0037ep643 | Obesity and cardiovascular endocrinology | ECE2015

Insulin resistance does not play a major role in lipid and apolipoprotein profile in obese women

Silva-Nunes Jose , Brito Miguel , Veiga Luisa

Background: Obesity is associated with increased atherogenesis through alterations in lipids, among other potential factors. Some of those abnormalities might be mediated by insulin resistance (IR).Aims: To compare lipid and apolipoprotein profile between lean and obese women; to evaluate the influence of IR on lipid and apolipoprotein profile, in obese women.Methods: We studied 112 obese and 100 normal-weight premenopausal women w...