Searchable abstracts of presentations at key conferences in endocrinology

ea0007p49 | Diabetes, metabolism and cardiovascular | BES2004

Increased C-jun N terminal kinase (JNK) activity may link insulin resistance and inflammation in human central obesity

Fowler A , Silva N , Burman C , Harte A , McTernan P , Kumar S

Central obesity is strongly associated with insulin resistance and chronic sub-clinical inflammation, which is implicated in the development of type 2 diabetes (T2DM). However, the mechanisms underlying this link remain unclear. Recently JNK, a mitogen activated protein kinase (MAPK), has been implicated in obesity and insulin resistance by interfering with insulin action. Studies in rodent models show that phosphorylated JNK-1 is elevated in obesity, whilst the absence of JNK...

ea0009p21 | Diabetes and metabolism | BES2005

Fatty liver disease is associated with both endotoxaemia and sub-clinical inflammation which is further aggravated by diabetes

Silva N , Harte A , Hill M , Kumar S , Day C , McTernan P

Obesity-mediated diabetes is associated with insulin resistance/hyperinsulinaemia and chronic sub-clinical inflammation. Recent studies have highlighted fatty liver(steatosis) as a risk factor for diabetes. Fatty liver disease (FLD) progresses through fatty liver, necro-inflammation (non-alcoholic steatohepatitis, NASH) and fatwith fibrosis. In addition, hepatic steatosis per se can lead to hepatic insulin resistance/hyperin...

ea0009p31 | Diabetes and metabolism | BES2005

Elevated endotoxin levels as a mediator of consistent chronic sub-clinical inflammation in CABG patients

Baker A , Silva N , Ranasinghe A , Pagano D , Bonser R , Kumar S , McTernan P

Chronic sub-clinical inflammation is associated with increased risk of type 2 diabetes and cardiovascular disease. Patients undergoing CABG are at high risk of further cardiovascular events and also demonstrate sub-clinical inflammation. We therefore investigated alterations in the relative balance between pro-inflammatory agents, such as hsCRP versus changes in anti-inflammatory factors (adiponectin) and as such the potential molecular pathways mediating these changes. The ai...

ea0007p50 | Diabetes, metabolism and cardiovascular | BES2004

Circulating pro-inflammatory cytokines and epicardial expression of resistin and TNF-alpha are increased in patients with cardiovascular disease

Baker A , Quinn D , Silva N , McTernan C , Harte A , Bonser R , Kumar S , McTernan P

Chronic sub-clinical inflammation is associated with increased risk of diabetes and cardiovascular disease and is particularly observed in patients that have undergone CABG. Resistin, a novel adipocyte derived protein, has been linked with central adiposity, insulin resistance and sub-clinical inflammation and may mediate both systemic and local paracrine pro-inflammatory responses in vivo. As such we investigated serum resistin from CABG patients and examined whether e...

ea0029p1624 | Thyroid (non-cancer) | ICEECE2012

Hyperthyroidism in patients with acute atrial fibrillation attended at an emergency room

Moreno C. , Esperto H. , Silva N. , Fonseca I. , Ruas L. , Vieira A. , Alves M. , Sofia G. , Saraiva J. , Nascimento Costa J. , Carvalheiro M.

Introduction: Atrial fibrillation (AF) is the most common cardiac complication of hyperthyroidism, with significant mortality and morbidity resulting from embolic events. In patients who attend at an emergency room (ER) with acute AF, the thyroid hormones aren’t usually evaluated given the low prevalence of hyperthyroidism in the general population.Aims: To assess the prevalence of thyroid dysfunction in adult patients who presented at an ER with ac...