Searchable abstracts of presentations at key conferences in endocrinology

ea0049oc2.5 | Diabetes Prediction and Complications | ECE2017

Urinary peptidomics for the detection of diabetic kidney disease

Brondani Leticia A , Soares Ariana A , D'Allagnol Angelica , Camargo Joiza L , Monteiro Karina , Silveiro Sandra P

Background: Diabetic kidney disease (DKD) is the main cause of end-stage renal disease It is defined by glomerular filtration rate (GFR) impairment and/or presence of increased urinary albumin excretion (UAE). However, these parameters are nonspecific and somewhat delayed manifestations of renal damage. Thus, earlier DKD new biomarkers are strongly warranted.Objective: To investigate the urinary peptidomics profile of type 2 diabetes mellitus (DM) patien...

ea0049ep457 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The T allele of the rs1746661G/T polymorphism in FNDC5 (irisin) gene is associated with increased systolic blood pressure

Brondani Leticia A. , Boucas Ana Paula , Assmann Tais S. , Reichelt Angela J. , Martins-Costa Sergio , Weinert Leticia S. , Silveiro Sandra P. , de Souza Bianca M. , Crispim Daisy

Background: Gestational diabetes mellitus (GDM) is a risk factor for type 2 diabetes and both conditions are characterized by insulin resistance (IR) and decreased insulin production by pancreatic beta-cells. FNDC5 gene encodes a type I membrane protein that is proteolytically processed to form a hormone secreted into the blood, termed irisin. After induction by exercise, irisin activates profound changes in the subcutaneous adipose tissue, stimulating browning and UCP1 gene e...