Searchable abstracts of presentations at key conferences in endocrinology

ea0035p702 | Male reproduction | ECE2014

Effect of 17β-estradiol on germ cell apoptosis by modulating the expression of SCF/c-kit, FasL/FasR and regucalcin

Correia Sara , Alves Mario R , Martins Ana D , Cavaco Jose E , Oliveira Pedro F , Socorro Silvia

In the last years estrogens have emerged as important regulators in male reproductive function. Spermatogenesis depends on the tight control of germ cell apoptosis and several studies indicated estrogens as playing a role in this process. The stem cell factor (SCF), a membrane-bound cytokine, and its receptor (c-kit), and the Fas ligand (FasL)/Fas receptor (FasR) system are powerful mechanisms controlling germ cell proliferation and apoptosis through the direct membrane commun...

ea0014p278 | (1) | ECE2007

SMP30 is expressed in rat mammary gland and down-regulated by estradiol

Maia Cláudio JB , Santos Cecilia RA , Schmitt Fernando , Socorro Silvia

The SMP30 (Senescence Marker Protein 30) is involved in the maintenance of intracellular Ca2+ homeostasis and in the regulation of various Ca2+- dependent proteins. A suppressive effect on cell proliferation, DNA synthesis and on the expression of oncogenes in rat hepatoma cells overexpressing SMP30 has been reported recently suggesting it may have a role in cancer progression. High levels of SMP30 expression have been found in liver and kidney of rats bu...

ea0035p571 | Endocrine tumours and neoplasia | ECE2014

Androgens regulate gene expression of glucose transporters and glycolytic enzymes in prostate cancer cells

Vaz Catia V , Alves Marco G , Marques Ricardo , Moreira Paula I , Oliveira Pedro F , Cavaco Jose E , Maia Claudio J , Socorro Silvia

Prostate cancer (PCa) is an endocrine tumor that presents distinct metabolic features associated with neoplastic development, namely in the transition from the androgen-dependent to the androgen-independent phenotype that characterizes advanced stages of prostate cancer. Recently, we have found that LNCaP (androgen-responsive) and PC3 (androgen-nonresponsive) PCa cells present distinct glycolytic metabolism profiles in consequence of altered gene expression and/or activity of ...

ea0014p276 | (1) | ECE2007

Transthyretin is up-regulated by androgens in mice liver and choroid plexus

Santos Cecilia RA , Henrique Alves C , Saraiva Maria Joao , Abreu Raquel , Baltazar Graça , Socorro Silvia , Quintela Telma P , Gonçalves Isabel MT

Transthyretin (TTR) is well documented as a carrier for thyroid hormones. It also binds retinol binding protein preventing its filtration trough the kidneys and therefore is involved in delivering retinol to target cells. Moreover, TTR sequesters amyloid-beta impairing its deposition in nervous tissues and possibly contributing to its removal. Despite its importance in mammalian physiology, there are few studies regarding the regulation of TTR synthesis. In silico analy...