Searchable abstracts of presentations at key conferences in endocrinology

ea0067gp15 | Poster Presentations | EYES2019

Challenges in the management of severe constipation due to metastatic paraganglioma

Figueiredo Ana Abrantes , Maciel Joana , Cavaco Daniela , Donato Sara , Simoes Helder , Simoes-Pereira Joana , Leite Valeriano

Background: Pheochromocytoma and paragangliomas (PPGLs) are rare disorders with a rate of malignancy of 10–20%. The control of the hormonal symptoms caused by the catecholaminergic burden in the metastatic disease is a challenging task. Hypertension is the most recognized feature, but gastrointestinal manifestations can be hard to manage and life-threatening.Cases Presentation: We present three cases of metastatic PPGLs who developed intestinal pseu...

ea0063p866 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Primary adrenal lymphoma: a rare cause of adrenal insufficiency

Maciel Joana , Simoes Helder

Background: Primary adrenal Non Hodgkin Lymphoma (NHL) accounts for less than 1% of all NHL cases. Among them, Diffuse Large B Cell Lymphomas (DLBCL) are the most commonly identified. Seventy percent of cases are bilateral and adrenal insufficiency usually occurs. Here we describe a case of a DLBCL with bilateral adrenal involvement and adrenal insufficiency.Clinical case: A 68 years male with a personal history of malaria, asthma, hypertension and chole...

ea0049ep1219 | Clinical case reports - Thyroid/Others | ECE2017

Struma ovarii – A report of thirteen cases

Donato Sara , Simoes Helder , Leite Valeriano

Introduction: Struma ovarii (SO) is a rare ovarian teratoma characterized by the presence of thyroid tissue in >50% of the tumour. Malignant transformation is rare and defined by the same histological criteria as for thyroid cancer. There is few data on the literature and treatment is controversial. The objective of this study was to describe the clinical, pathologic and treatment characteristics of women diagnosed with SO in our centre.Methods: Retr...

ea0049ep772 | Clinical case reports - Thyroid/Others | ECE2017

Immune checkpoint inhibitors related thyroiditis – a report of two cases

Donato Sara , Antunes Pedro , Simoes-Pereira Joana , Simoes Helder

Introduction: Immune checkpoint inhibitors (ICPIs) are recent approved drugs used in malignant melanoma, non-small-cell lung cancer and renal cell cancer. They act by activating host T cell against malignant antigens. Immune checkpoint blockade can lead to breaking of immune self-tolerance, thereby inducing autoimmune/autoinflammatory side effects, such as endocrinopathies. It may affect thyroid, adrenal and pituitary. We present two ICPIs induced thyroiditis cases.<p clas...

ea0056ep23 | Adrenal and Neuroendocrine Tumours | ECE2018

Intestinal pseudo-obstruction as a fatal complication of a malignant hereditary paraganglioma: A case report

Maciel Joana , Donato Sara , Simoes Helder , Leite Valeriano

Background: Familial paraganglioma type 1 syndrome is a hereditary form of paraganglioma due to an autosomal dominant, paternally inherited, germinal mutation in the SDHD subunit. Intestinal pseudo-obstruction is a rare complication of secretory PGL. We present a case of a patient with a malignant PGL syndrome type 1 who developed intestinal pseudo-obstruction.Clinical case: The patient was a Dutch male, aged 39 years, carrier of a germinal mutation in e...

ea0081ep76 | Adrenal and Cardiovascular Endocrinology | ECE2022

Pulmonary thromboembolism as the initial presentation of ACTH-independent Cushing’s Syndrome

Dias Daniela , Damasio Ines , Simoes Helder , Serra Filipa , Fontes Luisa , Leichsenring Carlos , Pinheiro Nuno , Sapinho Ines

Cushing’s syndrome (CS) is associated with a considerable risk of complications including thromboembolic events (TE). They occur mostly within the first 2–3 months postoperatively. When present before surgery, CS has high rates of perioperative mortality and morbidity. The benefit of steroidogenesis inhibitors after TE is not fully known. Furthermore, little guidance is available regarding TE assessment/management in CS. We report a case of a 34-year-old male admitte...

ea0049gp23 | Adrenal 3 | ECE2017

Clinical features and treatment outcomes in a group of SDHx-related pheochromocytoma/paraganglioma patients

Simoes Helder , Antunes Pedro , Pinto Ana , Donato Sara , Leite Valeriano , Cavaco Branca

Introduction: Germline mutations in succinate dehydrogenase complex (SDHx) are a risk factor for developing Pheochromocytoma (Pheo) and/or Paragangliomas (PGL) (named together PPGL), being responsible for approximately 30% of cases. The precise genotype-phenotype correlations and best management strategies are still uncertain.Objective: To characterize the clinical features and genotype-phenotype associations in a group of SDHx-mutated PPGL patients....

ea0049ep258 | Calcium &amp; Vitamin D metabolism | ECE2017

Parathyroid carcinoma: experience of a Portuguese centre

Bello Carlos Tavares , Donato Sara , Prazeres Susana , Simoes Helder , Leite Valeriano

Introduction: Parathyroid Carcinomas are rare malignant neoplasms, accounting for less than 1% of primary hyperparathyroidism cases. Apart from certain genetic mutations, no additional risk factors are known. Diagnosis is challenging in the absence of metastatic disease since no consensual histological criteria have so far been developed. These neoplasms typically present with severe hypercalcemia and markedly elevated serum PTH levels. Treatment is surgical and despite freque...

ea0041ep172 | Calcium and Vitamin D metabolism | ECE2016

Roux-en-Y Gastric Bypass reversal due to recalcitrant hypocalcaemia after total thyroidectomy

Silva Joao , Ivo Catarina , Simoes Helder , Lopes Luis , Passos Dolores , Marcelino Mafalda , de Castro Joao Jacome

Introduction: Hypocalcaemia is a potential post-thyroidectomy complication. Patients with previous Roux-en-Y Gastric Bypass (RYGBP) are at increased risk of symptomatic hypocalcaemia refractory to treatment. This complication is rare and there is not consensus on how to act.Clinic case: Female with 34 years old, with a history of Obesity (BMI 45.7 kg/m2), submitted to RYGBP in 2013, with a total loss of 47 kg (current BMI 27.3 kg/m2...

ea0041ep385 | Clinical case reports - Thyroid/Others | ECE2016

Thyroid, the Heart and Amiodarone

Ivo Catarina , Silva Joao , Simoes Helder , Monge Jose , Lopes Carlos , Marcelino Mafalda , Castro Joao Jacome de

Introduction: The hyperthyroidism is a risk factor for tachyarrhythmia and dilated cardiomyopathy. Amiodarone is an effective antiarrhythmic medication, however if coexisting thyroid pathology complicates the treatment of thyroid dysfunction. It presents a case of Graves’ disease (GD) of long evolution, which illustrates the complexity of these associations. Clinical case: man, 44 years old, smoker, history of acute myocardial infarction and GD diagnosed at age 28. Has ma...