Searchable abstracts of presentations at key conferences in endocrinology

ea0022p13 | Adrenal | ECE2010

Pharmacokinetic evidence for hydrococortisone under and over replacement in adrenal insufficiency

Castinetti Frederic , Simon Nicolas , Ouliac Floriane , Lesavre Nathalie , Brue Thierry , Oliver Charles

Aim and methods: Cortisol substitution in adrenal insufficiency (AI) is a matter of debate. We performed a pharmacokinetic analysis of plasma and salivary cortisol following oral hydrocortisone intake in patients with AI, and a pharmacokinetic modelling simulation. Fifty patients with primary (n=20) or secondary (n=30) AI were recruited. After 24-h plasma and salivary cortisol measurements under usual hydrocortisone treatment, a pharmacokinetic modelling with dif...