Searchable abstracts of presentations at key conferences in endocrinology

ea0081p679 | Pituitary and Neuroendocrinology | ECE2022

Efficacy, safety and metabolic impact of long-term pegvisomant therapy in acromegaly: results from a 10-year single center experience

Pirchio Rosa , Simona Auriemma Renata , Elena Montini Maria , Vergura Alice , Pivonello Rosario , Colao Annamaria

Pegvisomant (PEG) is effective in acromegaly control and exerts a positive impact on glucose metabolism. The current study aimed at investigating the effects of 10-years PEG treatment on disease control, pituitary adenoma size, and metabolic profile in patients with acromegaly resistant to somatostatin analogues (SRLs). Twenty-two patients (9 men,13 women, age 45.54 ± 12.83 years) treated with PEG for 10 years, in monotherapy or in combination with SRLs, were included in ...

ea0081p680 | Pituitary and Neuroendocrinology | ECE2022

Long-term pasireotide therapy: real life experience of a single referral center

Pirchio Rosa , Vergura Alice , Elena Montini Maria , Simona Auriemma Renata , Pivonello Rosario , Colao Annamaria

Pasireotide is a second-line therapy for acromegaly, that allows to obtain disease control in patients previously uncontrolled. However, pasireotide-induced hyperglycemia is of major concern. Currently, few data concerning prolonged use of pasireotide are available. The current retrospective study aimed at investigating the efficacy and safety of long-term pasireotide therapy. Sixteen consecutive patients (5 males, 11 females, age 47 ± 11 years) undergoing pasireotide for...

ea0081p64 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The bidirectional relationship between testosterone and metabolic disorders: testosterone deficiency as an early marker of cardiovascular risk in young men

Menafra Davide , De Angelis Cristina , Garifalos Francesco , Castoro Michele , Verde Nunzia , Piscopo Mariangela , Galdiero Giacomo , Pivonello Claudia , Simona Auriemma Renata , Chiodini Paolo , Colao Annamaria , Pivonello Rosario

In the last years an increasing incidence of cardiovascular diseases (CVD) has been reported in young adults (18-45 yrs), probably accounted by the significant increase in CV risk (CVR) factors. Observational and interventional studies, mainly focused on middle-aged and elderly men, demonstrated that metabolic CVR (mCVR) factors and CVD manifestations are common in hypogonadal men and, conversely, testosterone deficiency is highly prevalent in metabolic disorders; the lack of ...

ea0081p614 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Dopaminergic system and adipose tissue: in vitro effect of cabergoline on white, brown and beige adipogenesis and lipogenesis processes

Negri Mariarosaria , Pivonello Claudia , Amatrudo Feliciana , Patalano Roberta , Monto Tatiana , Angelis Cristina de , Simeoli Chiara , Simona Auriemma Renata , Colao Annamaria , Pivonello Rosario

Adipose tissue is an endocrine organ releasing adipokines and expressing specific markers and intracellular mediators, which regulate whole-body energy by balancing lipid accumulation and utilization through adipogenesis, the differentiation of preadipocytes into mature adipocytes associated with gradual lipid storage, and lipogenesis, the additional lipid accumulation in mature adipocytes. Adipogenesis and lipogenesis, strongly induced by insulin, occur in white adipocytes, s...

ea0081p682 | Pituitary and Neuroendocrinology | ECE2022

Berlin questionnaire and epworth sleepiness scale as screening tools of sleep apnea risk in patients with acromegaly: comparison of 144 patients and an age-and gender-matched health cohort

Pirchio Rosa , Addato Raffaele , Elena Montini Maria , Valentina De Santis Ciacci Corina , Vergura Alice , Simona Auriemma Renata , Pivonello Rosario , Colao Annamaria

Sleep apnea (SA) is a common acromegaly comorbidity, influencing patients’ quality of life and mortality risk. Despite its importance, SA frequently remains undiagnosed, and its real prevalence seems to be underestimated. The current observational study aimed at investigating the role of Berlin questionnaire (BQ) and Epworth sleepiness scale (ESS) in assessing the risk of SA in this high-risk population, and to compare the results with an age-and gender-matched health coh...

ea0081p708 | Reproductive and Developmental Endocrinology | ECE2022

The medical treatment of polycystic ovary syndrome: effects of inositol isomers and metformin on clinical, metabolic and hormonal profile

Verde Nunzia , Pellegrini Bianca , Auriemma Lucia , Baratto Alessia , De Angelis Cristina , Garifalos Francesco , Menafra Davide , Castoro Michele , Simeoli Chiara , Colao Annamaria , Pivonello Rosario , Simona Auriemma Renata

Polycystic ovary syndrome (PCOS) is characterized by menstrual irregularities and clinical and biochemical hyperandrogenism, and is associated with insulin resistance, visceral obesity and metabolic disorders. The aim of the current study was to compare the effects of inositol isomers (INO) and metformin (MET) on the clinical, metabolic and hormonal aspects of PCOS. In 94 PCOS women, clinical (weight, BMI, waist circumference - WC, menstrual intervals, Ferriman-Gallway score -...

ea0041ep583 | Endocrine Disruptors | ECE2016

Thyroid diseases in the ‘Land of Fires’: results of a single center screening in Acerra (Naples)

Simona Auriemma Renata , Cozzolino Mariaconcetta , Belli Arturo , Fierro Gaetano , Messina Gaetana , De Luca Renato , De Simone Teresa , Rivezzi Matteo , Galdiero Mariano , de Angelis Cristina , Pivonello Rosario , Colao Annamaria

Introduction: Environmental toxins, including those deriving from illegal and hazardous disposal of urban and chemical waste, are known to act as endocrine disruptors and to increase the risk of malignancy and cancer mortality. The present study aimed at investigating prevalence and characteristics of thyroid diseases in the area of Acerra, a town in the perimeter of the so called ‘Land of Fires’.Methods: The screening included subjects aged &#...

ea0070aep10 | Adrenal and Cardiovascular Endocrinology | ECE2020

Cortisol rhythm in patients with adrenal insufficiency switched from conventional glucocorticoids to dual release hydrocortisone: Impact on metabolic profile

Simeoli Chiara , Iacono Marina , Ferrigno Rosario , Negri Mariarosaria , Pivonello Claudia , Simona Auriemma Renata , De Martino Maria Cristina , Colao Annamaria , Pivonello Rosario

Background: Several evidences suggested that conventional glucocorticoids (CGCs) used as replacement treatment in adrenal insufficiency (AI) are inadequate to mimic physiological cortisol circadian rhythm (CCR), and that CCR disruption, represented by non-physiological pattern of peaks and troughs and elevated evening GC levels, might be responsible for the increased metabolic and, consequently, cardiovascular risk. It has been demonstrated that once daily dual-release-hydroco...

ea0070aep341 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Anti-Lipogenic effects of cabergoline: A molecular study on white adipocytes

Negri Mariarosaria , Pivonello Claudia , Amatrudo Feliciana , Gentile Annalisa , Montò Tatiana , Patalano Roberta , Simeoli Chiara , Ferrigno Rosario , Simona Auriemma Renata , Colao Annamaria , Pivonello Rosario

Obesity is caused by an imbalance between dietary energy intake and expenditure. The expression of dopamine receptors (DRs) in human adipocytes has been already demonstrated. Moreover, the effects of cabergoline, a dopamine agonist, on body weight and glucose homeostasis in obese subjects without hyperprolactinemia has already been reported. The current study investigates the effects of cabergoline on lipid accumulation and on adipogenic factors expression to better define the...

ea0070aep530 | Endocrine-related Cancer | ECE2020

Reversal effect of Vitamin D (VitD) on exosome-mediated everolimus resistance (EveR) in hepatocellular carcinoma (HCC) cell line: A molecular study

Gentile Annalisa , Negri Mariarosaria , Montò Tatiana , Patalano Roberta , de Angelis Cristina , Simeoli Chiara , Ferrigno Rosario , Cristina De Martino Maria , Simona Auriemma Renata , Colao Annamaria , Pivonello Rosario , Pivonello Claudia

Cancer exosomes emerged as important mediators of cancer drug resistance. Drug exposure-mediated EveR in HCC cell lines can be reversed by VitD pre- and co-treatment. The current study aimed to investigate whether cancer exosomes from EveR HCC cell line are able to induce EveR in parental cells and whether VitD may activate reversal effect on exosome-mediated EveR.To this purpose, parental JHH-6 and EveR JHH-6 cell line were used. The uptakeof exosomes, ...