Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1768 | Thyroid cancer | ICEECE2012

Nursing assistance increases the efficiency of ultrasound-guided fine-needle aspiration biopsy (US-FNAB) in the management of thyroid nodules: the MoCyThy (Modena's Cytology of the Thyroid) DATABASE

Belli S. , Carani C. , Ansaloni A. , Cioni K. , Zirilli L. , Velasco M. , Simoni M. , Madeo B. , Rochira V.

Introduction: US-FNAB is the most cost/effective and accurate diagnostic procedure for the evaluation of thyroid nodules. In the clinic, the nursing assistance is not always available for the US-FNAB procedure in all endocrinological centers and its value remains to be established.Aim of the Study: To demonstrate the role of nursing assistance in US-FNAB procedures in improving the efficiency of this procedure.Methods: All clinical...

ea0029s53.3 | Genetic polymorphism in reproduction | ICEECE2012

Genetic complexity of FSH receptor function

Simoni M.

FSH acts via binding to its specific receptors, the FSHR, possessing a large number of SNPs. The FSHR SNPs at nucleotide position 919 and 2039 in exon 10 are very common (heterozygosity: 0.469) and result in the aminoacid transition Thr/Ala at codon 307 and Asn/Ser at codon 680 respectively. In addition a G/A SNP is found in the promoter region at position −29, with the G allele covering 75% and the A allele 25% of the alleles in Caucasians. In turn, the FSHB gene, encod...

ea0029p623 | Diabetes | ICEECE2012

Effects of chronic administration of Vardenafil on endothelial function in patients with type 2 diabetes mellitus. A longitudinal, randomized, placebo-controlled, double blind, non-sponsored clinical trial

Santi D. , Guidi A. , Granata A. , Simoni M. , Carani C.

Introduction: The endothelium produces molecules regulating vascular function, such as nitric oxide (NO). NO protects blood vessels from endogenous injury and causes vasodilation through activation of second messengers. In diabetes mellitus (DM), hyperglycemia provokes oxidative stress, reduction of NO and increased synthesis of vasoconstrictors (e.g. endothelin). Cyclic nucleotide phosphodiesterases (PDEs) are enzymes, controlling the rate of degradation of second messengers....

ea0029p1051 | Male Reproduction | ICEECE2012

Ten years of EAA/EMQN quality control scheme for microdeletions of the Y chromosome

Tuttelmann F. , Hoefsloot L. , Patton S. , Simoni M. , Krausz C.

Introduction: Y-chromosomal azoospermia factor (AZF) microdeletions are one of the few well-established genetic causes of male infertility, specifically azoospermia or severe oligozoospermia. Since the introduction of a PCR-based method to easily detect the distinct deletion patterns, the screening of infertile men for Y microdeletions has become a very common genetic test performed frequently by a large number of laboratories. An external quality control scheme was establishe...

ea0011p645 | Reproduction | ECE2006

Spermatogenesis in autologous testicular transplants in the non-human primate Callithrix jacchus

Luetjens CM , Schlatt S , Nieschlag E , Simoni M , Wistuba J

Immature testicular tissue was successfully xenografted in several species but did not lead to spermatogenesis with tissue obtained from the non-human primate Callithrix jacchus. Previous data indicate that the microenvironment provided by the mouse host might cause this failure. We conducted an in vivo study performing autologous ectopic transplantation of testicular fragments in newborn anaesthetised marmoset monkeys and compared transplanted animals to sham op...

ea0083rdo2 | Reproductive and Developmental Endocrinology | EYES2022

Ketogenic state is able to improve testosterone serum levels - a meta-analytic approach

C. Furini , G Spaggiari , C. Greco , M. Simoni , D. Santi

Background: It is widely demonstrated that obesity and hypogonadism are bi-directionally correlated, since the hypogonadism prevalence is higher in obese population, while weight loss increases testosterone serum levels. Several approaches are available to contrast weight excess, from simple dietary regimens to more complex surgical procedures. Ketogenic diets (KD) fit in this context and their application is growing year after year, aiming to improve the metabolic and weight ...

ea0029p1010 | Male Reproduction | ICEECE2012

Prevalence of olfactory and other developmental anomalies in patients with central hypogonadotropic hypogonadism

Valle E. Della , Vezzani S. , Rochira V. , Granata A. , Carani C. , Genovese E. , Simoni M.

Introduction: Hypogonadotropic hypogonadism (HH) is a heterogenous disease caused by mutations in several genes. Based on the presence of hyposmia/anosmia it is distinguished into Kallmann syndrome and isolated HH. The prevalence of other developmental anomalies is not well established.Methods: We studied patients with HH (29 males, 3 females, mean age 41.5), 9 with familial and 23 sporadic HH (29 congenital, 3 adult-onset), by physical examination, smel...

ea0029p1549 | Steroid metabolism + action | ICEECE2012

The cellular fate of CYP19A1 (aromatase) protein

Pignatti E. , Ferioli S. , Carani C. , Rochira V. , Poti F. , Simoni M.

Introduction: Aromatase cytochrome P450 is uniquely responsible for estrogen synthesis in vertebrates. The protein is expressed in the gonads and other extraglandular tissues. Deregulated expression of aromatase has pathological relevance and targeting the CYP19A1 product could be an effective strategy for treatment of affected tissues. Nevertheless, very little is known concerning the role of protein oligomerisation, glycosylation and degradation. Here we studied the aromatas...

ea0029p1763 | Thyroid cancer | ICEECE2012

Ultrasound-guided fine-needle aspiration biopsy (US-FNAB) of thyroid nodules: effects of the operator’s experience on adequacy of sampling: the MoCyThy (Modena’s Cytology of the Thyroid) DATABASE

Vezzani S , Ansaloni A , Zirilli L , Cioni K , Diazzi C , Simoni M , Madeo B , Rochira V

Introduction: Thyroid FNAB is the gold standard to discriminate malignant from benign thyroid nodules. However, inadequate cytology ranges from 1 to 20% (up to 33.6%) in different settings and could depend on several factors, including the operator’s skills.Aim: To evaluate the effect of operator’s experience on US-FNAB diagnostic adequacy we reviewed 7029 US-FNABs performed from January 2006 to March 2009.Materials and M...

ea0029p1772 | Thyroid cancer | ICEECE2012

Incidence of ultrasound thyroid scan anomalies in healthy volunteers in modena, italy

Gnarini V. , Brigante G. , Della Valle E. , Taliani E. , Carani C. , Simoni M.

Introduction: We assessed the incidence of ultrasound (US) thyroid scan anomalies in adult volunteers in the district of ModenaMethods: From December 2010 to October 2011 we performed US thyroid scan (Siemens Acuson Antares, 10 Mega Hertz-Linear scanner- B mode) in a cohort of 201 volunteers, recruited by local advertisement, women (n=135) and men (n=66), mean age 46±10.7. All participants were unaware of any thyroid disease and at the...