Endocrine Abstracts

IntroductionIn higher vertebrates, the main population of forebrain GnRH1 neurons originate in the embryonic olfactory placode. Early migration of GnRH neurons in mice - from the nasal placode into the nasal mesenchyme - depends on NELF (nasal embryonic LHRH factor). Furthermore, migratory GnRH cells express the leptin receptor. The precise role(s) of leptin during neuroendocrine GnRH development are unknown but it may combine with Neuropeptide Y (NPY) t...