Searchable abstracts of presentations at key conferences in endocrinology

ea0019p95 | Clinical practice/governance and case reports | SFEBES2009

An audit of thyroid surveillance in amiodarone treated subjects – room for improvement

Singh Prashant , Drodge A , Premawardhana LDKE

Introduction: Thyroid dysfunction is relatively common in amiodarone treated subjects, partly because of its high iodine content. The benefits of surveillance, early identification and management of such thyroid dysfunction have been established. We undertook a retrospective case notes audit of all amiodarone treated subjects in our hospital to evaluate thyroid surveillance and outcome.Methods: All patients treated with amiodarone between 2001 and 2004 w...

ea0050ep034 | Bone and Calcium | SFEBES2017

A rare case of combined hyperparathyroidism and thymoma

Basavaraju Navya , Singh Prashant , Moulik Probal , Rangan Srinivasa

: A 67-year-old lady, previously fit and well, presented with chest pain. She denied gastrointestinal or urological symptoms. There was no history of depression, psychosis, previous hip fracture or steroid use. She had regular menstrual cycles until hysterectomy at 50 years of age. She doesn’t smoke or drink alcohol. Her mother and father had oesophageal and lung cancer respectively with no family history of hypercalcemia. On examination, she was normotensive with BMI 23....

ea0050ep034 | Bone and Calcium | SFEBES2017

A rare case of combined hyperparathyroidism and thymoma

Basavaraju Navya , Singh Prashant , Moulik Probal , Rangan Srinivasa

: A 67-year-old lady, previously fit and well, presented with chest pain. She denied gastrointestinal or urological symptoms. There was no history of depression, psychosis, previous hip fracture or steroid use. She had regular menstrual cycles until hysterectomy at 50 years of age. She doesn’t smoke or drink alcohol. Her mother and father had oesophageal and lung cancer respectively with no family history of hypercalcemia. On examination, she was normotensive with BMI 23....

ea0082wd8 | Workshop D: Disorders of the adrenal gland | SFEEU2022

Atypical late presentation of congenital adrenal hyperplasia with adrenal myelolipomas

Idris Izan , Basavaraju Navya , Moulik Probal , Rangan Srinivasan , Singh Prashant

64 y/o male was being investigated for raised PSA. Following an MRI and biopsy, he was diagnosed with high grade prostatic intraepithelial neoplasia requiring close PSA surveillance. Incidentally, he was found to have bilateral adrenal lesions, measuring 6.4 cm on the left and 4 cm on the right. Prior to review in endocrine clinic, adrenal workup and CT adrenals were performed. CT showed both adrenal masses contain fat and calcification and are thought to be bilateral adrenal ...

ea0065p43 | Adrenal and Cardiovascular | SFEBES2019

An unusual pathology presenting as adrenal incidentaloma

Vijay Arun , Moulik Probal , Singh Prashant , Rangan Srinivasa

Introduction: Adrenal Incidentalomas (AI) are frequently encountered in clinical practice with radiological studies suggesting a frequency of 3% at 50 years rising to 10% in elderly. Majority of AI are non functional adenomas with malignant lesions quoted as less than 20% at most. We report a case of AI, which was found to a Melanoma on biopsy with no other primary site.Case: An 84 year old gentleman was found to have a right suprarenal mass on ultrasoun...

ea0065p165 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

A case of pituitary metastatic deposit from breast cancer

Vijay Arun , Rangan Srinivasa , Singh Prashant , Moulik Probal

Introduction: Metastatic lesion in the pituitary is a rare condition with most of them being asymptomatic. Breast cancer is the most frequent primary location and the overall prognosis is poor. We describe the case of a lady with this condition, who presented to our unit with bitemporal hemianopia.Case: A 65 year old lady with history of breast cancer (surgical excision with chemoradiotherapy 4 years ago, HER2 negative, currently in remission) presented ...

ea0065p330 | Neuroendocrinology | SFEBES2019

An unusual case of orthostatic hypertension likely secondary to dysautonomia

Vijay Arun , Singh Prashant , Rangan Srinivasa , Moulik Probal

Introduction: Orthostatic hypertension (OHT) is a phenomenon which may represent increased cardiovascular risk and is less well recognized compared to orthostatic hypotension.Case: A 65 year old gentleman presented with symptoms of lethargy and episodic shaking. He has a history of treated prostate cancer and was not on any regular medications. He noticed consistently elevated blood pressure on standing during home monitoring. His lying BP was 142/82 and...

ea0044ep39 | (1) | SFEBES2016

A young person with recurrent severe hypokalaemia - familial, iatrogenic or just unknown?

Shafqat Muhammad , Basavaraju Navya , Rangan Srinivasa , Singh Prashant , Moulik Probal

A 26-year-old female presented with 5-year history of episodic muscle weakness, abdominal cramps and facial paresthesia. She had 2 hospital admissions elsewhere within 6months with severe hypokalaemia (1.9 mmol/L). She was started on Lamotrigine for epilepsy 7 years ago and changed to Levetiracetam in October 2010 following further seizures. She is now seizure-free for over 5 years. Her potassium levels before and after Levetiracetam are shown in Table 1.<table boarder="1"...

ea0021p64 | Clinical practice/governance and case reports | SFEBES2009

A man with short stature and absent testis

Singh Prashant , Pickett Pat , Rooproy Adwin , Moulik Probal , Macleod Andrew

A 63-year-old phenotypic male presented with absent testis and enlarged adrenal glands. He had attended the urology clinic for persistent microscopic haematuria. He was found to have an empty scrotum and hypospadias. The patient recalled having genital surgery in childhood but could not recall any endocrine assessment. He was taller than his peers in early childhood but stopped growing after age 13 years. He described himself as ‘potent’. He was unmarried and did not...

ea0054oc2 | (1) | NuclearReceptors2018

Stage-specific and global functions of NCOR2 in prostate cancer progression

Long1 Mark D , Singh Prashant K , Llimos Gerard , Rosario Spencer , Smiraglia Dominic , Campbell Moray J

The corepressor NCOR2/SMRT regulates multiple nuclear receptors (NRs) and other transcription factors. Disruption to these functions are implicated in prostate cancer (PCa) progression but the details remain enigmatic. Therefore we sought to define the global functions of NCOR2/SMRT using isogenic PCa cell models, PCa mouse models and human PCa cohorts.We mapped the NCOR2 dependent transcriptome (RNA-seq), miRnome (miRNA-seq), methylome (EPIC methylation...