Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc11.4 | Reproductive endocrinology II | ECE2007

EGFR ligands mediate key events of female reproduction: reduced litter size due to impaired fertilization in a transgenic mouse model

Schneider Marlon R. , Gratao Ana A. , Dahlhoff Maik , Sinowatz Fred , Wolf Eckhard

EGFR ligands, a family of seven related peptide growth factors, are emerging as key factors regulating different aspects of female reproduction including oocyte maturation and ovulation, and implantation. Betacellulin (BTC) is a rather neglected EGFR ligand whose biological activities have been mostly associated with the endocrine pancreas. During the routine breeding of recently established BTC transgenic mouse lines (Schneider et al., Endocrinology 146, 5237–5246, 2005)...