Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep13 | Adrenal cortex (to include Cushing's) | ECE2016

Immunohistochemical characteristics of blood vessels in non-visualized and visualized on MRI pituitary adenomas in patients with Cushing’s disease (pilot study)

Voronkova Iya , Belaya Zhanna , Khandaeva Patimat , Rozhinskaya Liudmila , Vorontsov Alexander , Sitkin Ivan , Grigoriev Andrey , Melnichenko Galina

Introduction: Regardless of improvements in MRI, up to 20% of ACTH-secreting pituitary tumors are only identified at surgical exploration. The objective was to estimate whether there is any difference in blood vessels and the subsequent ability to uptake contrast agent in visualized micro-adenomas as compared to non-visualized on MRI ACTH-secreting pituitary tumors.Materials and methods: Retrospective evaluation of ACTH-positive pituitary tumors from pat...

ea0070aep569 | Pituitary and Neuroendocrinology | ECE2020

Difference in plasma miRNA levels in inferior petrosal sinus samples from patients with ACTH-dependent Cushing’s syndrome as assessed by next-generation sequencing (NGS).

Belaya Zhanna , Malygina Anastasia , Nikitin Alexey , Koshkin Philipp , Sitkin Ivan , Rozhinskaya Liudmila , Melnichenko Galina , Dedov Ivan

Introduction: ACTH-secreting pituitary adenoma tissue differs from normal pituitary gland tissue in microRNA (miR) expression. MiRs are secreted into circulation and can be detected as potential biomarkersAim: To evaluate the difference in miR levels in plasma samples drained from inferior petrosal sinuses in patients with Cushing’s disease (CD) and ectopic-ACTH syndrome (EAS).Materials and methods: we enrolled 24 patients wi...

ea0056p2 | Adrenal cortex (to include Cushing's) | ECE2018

Endogenous stimulation in adrenal venous sampling (AVS) in differential diagnosis of primary hyperaldosteronism (PA)

Rybakova Anastasia , Sitkin Ivan , Kolesnikova Galina , Platonova Nadezda , Troshina Ekaterina , Romanova Natalia , Beltsevich Dmitry

Relevance: Due to numerous causes of PA, AVS allows differentiating variant nosological forms of PA. The importance of differential diagnosis is due to the fact that surgery is reasonable only with unilateral variant of PA, while in idiopathic hyperaldosteronism surgery isn’t a method of choice.Purpose: To assess the diagnostic possibilities of using AVS against the background of endogenous stimulation of adrenocorticotropic hormone (ACTH) in the ea...

ea0037gp.22.07 | Pituitary–Therapy of Cushing's disease | ECE2015

Neurosurgery outcome in patients with Cushing's disease with and without visualised pituitary adenoma on MRI, who underwent inferior petrosal sinus sampling

Belaya Zhanna , Khandaeva Patimat , Rozhinskaya Ludimila , Vorontsov Aleksandr , Sitkin Ivan , Grigoriev Andrey , Ivashenko Oksana , Dzeranova Larisa , Melnichenko Galina

Objective: To estimate the outcome of neurosurgery in patients with Cushing’s disease (CD) with and without pituitary adenoma visualisation on MRI.Material and methods: Patients with confirmed CD (11.2008–11.2014) by both inferior petrosal sinus sampling (IPSS) and histological evaluation after neurosurgery were enrolled into the study. Subjects were referred for IPSS because of non-visualised pituitary adenoma or contradictory results of non-i...

ea0056oc8.1 | MicroRNAs as biomarkers in endocrine diseases | ECE2018

Plasma microRNA expression in patients with Cushing’s disease differs from ACTH-ectopic Cushing’s syndrome

Belaya Zhanna , Khandaeva Patimat , Nikitin Alexey , Solodovnikov Alexander , Sitkin Ivan , Grebennikova Tatjana , Vorontsov Alexander , Rozhinskaya Liudmila , Melnichenko Galina , Dedov Ivan

According to previous research microRNA (miR) are expressed differently in corticotropinoma and ACTH-secreting neuroendocrine tumors. MiR are released into circulation by several mechanisms and considered to be promising biomarkers.Objective: To evaluate whether preselected miR are differently expressed in plasma samples of patients with ACTH-dependent Cushing’s syndrome (CS).Materials and methods: The blood samples were colle...

ea0081ep642 | Pituitary and Neuroendocrinology | ECE2022

Circulating plasma microRNA in patients with ACTH-dependent cushing’s syndrome.

Malygina Anastasia , Belaya Zhanna , Solodovnikov Alexander , Nikitin Alexey , Koshkin Philipp , Sitkin Ivan , Pikunov Michael , Khandaeva Patimat , Lutsenko Alexander , Trukhina Diana , Lapshina Anastasia , Grigoriev Andrey , Melnichenko Galina , Dedov Ivan

Introduction: Recent studies have shown that microRNA could serve as biomarkers in various types of cancer and other diseases. Aim: To reveal microRNA that differ in patients with Cushing’s diseases (CD) and Ectopic ACTH-syndrome (EAS) to form a specific panel for differential diagnosis of ACTH-dependent Cushing’s syndrome (CS).Materials and Methods: Plasma samples from both sinuses and cubital vein were drained during in...