Searchable abstracts of presentations at key conferences in endocrinology

ea0014s4.2 | Gastroenteropancreatic endocrine tumors | ECE2007

Biological, morphological work-up and screening for inherited disease

Skogseid Britt

Pancreatic endocrine tumors (EPT) may occur sporadically or in association with the rare autosomal dominantly inherited tumor syndromes; multiple endocrine neoplasia type 1 (MEN1) and von Hipple Lindau (VHL). The genes causing these syndromes have been identified, and genotyping is possible which enables the laborious clinical investigations for diagnosis of lesions to be restricted to 50% of family members. For MEN1, no clinically useful genotype-phenotype correlation as been...

ea0081ep587 | Endocrine-Related Cancer | ECE2022

Poor outcome of systemic therapy in secondary high-grade pancreatic neuroendocrine tumors

Mollazadegan Kazhan , Skogseid Britt , Botling Johan , AEkerstrom Tobias , Eriksson Barbro , Welin Staffan , Anders Sundin , Crona Joakim

Introduction: Longitudinal changes in pancreatic neuroendocrine tumor (panNET) cell proliferation correlate with fast disease progression and poor prognosis. The optimal treatment strategy for secondary panNET grade (G)3, that has progressed from a previous low- or intermediate-grade to high-grade panNET G3 is currently unknown. Methods: This was a single center retrospective cohort study, aimed to characterize treatment patterns and outcomes among patie...

ea0014oc4.5 | Neuroendocriology basis | ECE2007

Lack of nuclear Hes1 expression coincides with transformation of endocrine pancreatic cells in Men1 knock out mice

Johansson Térèse , Lejonklou Margareta Halin , Skogseid Britt

Background: Homozygous inactivation of the MEN1 tumor suppressor gene frequently occurs in endocrine pancreatic tumors (EPT); however, a heterozygous germ line inactivation of the gene seems to lead to development of an increase amount of endocrine pancreatic cells. The Notch signaling cascade plays a vital role in sustaining the balance between cell proliferation, differentiation and apoptosis during pancreatic development. Whether Notch signaling is MEN1 depend...

ea0014p108 | (1) | ECE2007

Ascl1 is abundantly expressed in endocrine pancreatic tumors

Johansson Téresè , Halin Lejonklou Margareta , Ekeblad Sara , Stålberg Peter , Skogseid Britt

Background: Apart from inactivation of the MEN1 gene, molecular events essential for tumorigenesis of the endocrine pancreas are poorly characterized. A potentially useful approach for understanding tumor progression is to study transcription factors operating in fetal pancreatic development. The Notch signaling cascade with expression of the transcription factors Hes1, Hey1, and Ascl1 plays a vital role in sustaining the balance between cell prolif...

ea0026oc2.1 | Neuroendocrinology | ECE2011

Etoposide, doxorubicin, cisplatin, and mitotane versus streptozotocin and mitotane in adrenocortical carcinoma: preliminary results from the first international phase III trial: the FIRM-ACT study

Fassnacht Martin , Terzolo Massimo , Allolio Bruno , Baudin Eric , Haak Harm , Berruti Alfredo , Mueller Hans-Helge , Skogseid Britt

Background: No randomized trials have been conducted in adrenocortical carcinoma (ACC) patients. Treatment recommendations for this rare but aggressive disease have been based on data from small phase II trials. We have now performed the first randomized phase III trial, comparing etoposide, doxorubicin, cisplatin, plus mitotane (EDP-M) against streptozotocin plus mitotane (Sz-M).Methods: Three-hundred and four chemotherapy-naive patients with ACC not am...