Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep24 | Adrenal cortex (to include Cushing's) | ECE2016

Identified mutations in CYP11B1 gene in two Tunisian patients with 11-beta hydroxylase deficiency

Ennaifer Houda , Kammoun Ines , Kharrat M , Cheikrouhou Nessrine , Khatib Maria , Trabelsi M , Slama Claude Ben

Introduction: 11β-Hydroxylase deficiency (11β-OHD), caused by CYP11B1 mutations, is characterized by hyporeninemic, hypokalemic hypertension and hyperandrogenism. We studied the mutations of CYP11B1 gene in two patients with classic 11β-OHD.Observations: We present the first case of a 23 year old boy with preliminary diagnosis of 21 β-OHD diagnosed at the age of 10. The patient presented with hypertension and hypokalemia which were ag...

ea0041ep186 | Calcium and Vitamin D metabolism | ECE2016

Calcium intake in Tunisian postmenopausal women: evaluation and impact on diabetes

Grira Wafa , Kandara Hajer , Zoubeidi Hana , Enneifer Houda , Salem Leila Ben , Slama Claude Ben

Introduction: Calcium intake is important to prevent osteoporosis in postmenopausal women. The objectives of our study were to evaluate the daily dietary calcium intake in postmenopausal Tunisian women, to compare diabetic and non-diabetic postmenopausal women in their calcium intake and finally to propose corrective interventions to promote calcium intake and minimize the complications of menopause.Subjects and methods: The study involved 73 postmenopau...

ea0041ep325 | Clinical case reports - Pituitary/Adrenal | ECE2016

Association of TSH secreting adenoma and meningioma: a case report

Cheikhrouhou Nesrine , Salem Leila Ben , Haouat Emna , Sfar Haifa , Kamoun Ines , Slama Claude Ben

Introduction: TSH-secreting pituitary adenomas are rare pituitary functioning tumors accounting for <2% of the pituitary adenomas. Their association to meningiomas is a very rare condition.We report a case of 55-year-old woman who had multinodular goiter with mild symptoms of hyperthyroidism. Blood tests showed inappropriate secretion of TSH and magnetic resonance imaging (MRI) revealed a pituitary tumor with maximum diameter of 13 mm that was extirp...

ea0041ep692 | Female Reproduction | ECE2016

Resistant macroprolactinoma and infertility: a difficult challenge

Cheikhrouhou Nesrine , Kammoun Ines , Khatib Maria , Fennira Emna , Salem Leila Ben , Slama Claude Ben

Introduction: Dopamine agonist resistance is rare in prolactinoma (10%). Doses of cabergoline of up to 2.0 mg/week are usually effective in controlling prolactin (PRL) secretion and reducing tumor size. Surgical treatment is rarely indicated.Case report: An 18-year-old female presented in 2002 with a 2-year history of amenorrhea and galactorrhea. Hormonal investigation showed a hyperprolactinemia (4800 mUI/l) with integrity of the other pituitary axis. T...

ea0041ep698 | Female Reproduction | ECE2016

Can weight loss reverse polycystic ovary syndrome?

Grira Wafa , Kammoun Ines , Zoubeidi Hana , Sfar Hayfa , Salem Leila Ben , Slama Claude Ben

Introduction: Weight loss is a mainstay in the treatment of polycystic ovary syndrome (PCOS). While the cause of this complex endocrine disorder remains unknown, it’s approved that weight loss improves symptoms of PCOS. We report a case of a patient with PCOS. Her symptoms disappeared totally after losing 50kgCase report: In 2005, a 16-year-old girl presented for evaluation of spaniomenorrhoea and obesity. Physical examination showed a weight of 88 ...

ea0037ep1212 | Clinical Cases–Pituitary/Adrenal | ECE2015

Hyperprolactinaemia and breast abscess: is there a link?

Rojbi Imen , Haouat Emna , Kandara Hajer , Saada Basma , Hachmi Leila Ben Salem , Slama Claude Ben

Introduction: Hyperprolactinemia is a common endocrine condition causing galactorrhoea. Breast abscess is a frequent complication of the post partum period and breast feeding but it rarely occurs out of these two situations. We report the case of a patient presenting with tumoural hyperprolactinaemia associated with a breast abscess.Case report: A 34 years-old patient presented with galactorrhoea, spaniomenorrhoea and headache for six months. She had not...

ea0032p438 | Diabetes | ECE2013

Assessment of hypoglycemia risk factors in insulin treated patients

Maiza Mouna , Haouat Emna , Turki Zinet , Kandara Hajer , Salem Leila Ben , Slama Claude Ben

Achieving glycemic targets is crucial in the management of diabetes mellitus. Insulin is the most effective hypoglycemic treatment for diabetes but its use can be associated with a risk of hypoglycemia.The aim of this study is to specify risk factors of hypoglycemia in insulin-treated patients.Patients and methods: This transversal study included 69 patients. They were females in 49.4% of cases (n=41). Mean age was 52 year...

ea0032p590 | Female reproduction | ECE2013

Gynecological aspects of prolactinoma

Abdesselem Haifa , Haouat Emna , Salem Leila Ben , Kandara Hajer , Turki Zinet , Slama Claude Ben

Prolactinoma is a pituitary adenoma producing prolactin. Central hypogonadism is a major consequence of prolactinoma leading, in women, to menstrual troubles and infertility. The aim of this study was to specify gynecological characteristics of prolactinomas.Patients: This retrospective study included 28 female patients with prolactinoma. Mean age at diagnosis was 35.46 years (ext: 20–78). Mean serum prolactin level was 3442.4 ng/ml (ext: 31.9–...

ea0032p949 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Prolactinoma: does the size affect the signs?

Abdesselem Haifa , Haouat Emna , Salem Leila Ben , Laanani Amira , Turki Zinet , Slama Claude Ben

Introduction: Generously supported by IPSEN)-->Prolactinoma is the commonest pituitary adenoma. The aim of this study was to compare clinical, biological and radiological characteristics in microprolactinoma and macroprolactinoma.Patients: This retrospective study included 33 patients with prolactinoma. The tumor was a microadenoma (<1 cm) in 27.3% (n=9) and a macroadenoma in 72.7% (n=24) ...

ea0020p505 | Obesity and Metabolism | ECE2009

Anthropometric parameters and non alcoholic hepatic steatosis in type 2 diabetes

Hachmi Leila Ben Salem , Bouzid Chiraz , Farhat Leila Ben , Dorai Azza , Waghlani Ridha , Hendaoui Lotfi , Slama Claude Ben

Aim: The aim of the study was to assess the association between anthropometric parameters and non alcoholic hepatic steatosis in type 2 diabetes.Methods: Computed tomography imaging was used to assess hepatic fat content in 80 men and women with type 2 diabetes. Inclusion criteria included a confirmed diagnosis of type 2 diabetes (≥1 year of duration), without history of hepatic disease or daily consumption of alcohol drink. Clinical and biochemica...