Searchable abstracts of presentations at key conferences in endocrinology

ea0022p507 | Growth factors | ECE2010

GH modulates migration of developing T cells

Dardenne Mireille , Smaniotto Salete , Da Cruz Daniela Mendes , Savino Wilson

In the context of the cross-talk between the neuroendocrine and immune systems, it is well known that GH exerts physiological effects in central as well as peripheral compartments of the immune system. GH modulates a variety of thymic functions. For example, GH upregulates proliferation of thymocytes and thymic epithelial cells. Accordingly, GH-transgenic mice, as well as animals and humans treated with exogenous GH, exhibit an enhanced cellularity in the organ. GH also stimul...

ea0020oc2.2 | Diabetes & Obesity | ECE2009

Thymocyte migration is impaired in NOD mice: combined role of extracellular matrix and chemokines

Mendes-da-Cruz Daniella , Bauer Moises , Smaniotto Salete , Keller Alexandre , Savino Wilson , Dardenne Mireille

The NOD (non-obese diabetic) mouse remains the best experimental model of type I diabetes. We have previously described several thymic dysfunctions in these animals, including the presence of giant perivascular spaces (PVS) with arrest of mature T cells (including Treg cells) and partial impairment on fibronectin/VLA-5-dependent NOD thymocyte migration. Herein, we further studied the role of extracellular matrix (ECM) ligands, alone or in combination with the chemokine CXCL12 ...