Searchable abstracts of presentations at key conferences in endocrinology

ea0022s5.3 | Novel targets for thyroid cancer treatment | ECE2010

Tyrosine kinase inhibitors in thyroid cancer

Smit Johannes

Although the role of radioiodine (RaI) in recurrent or metastatic thyroid cancer is beyond dispute, the efficacy of this therapy is hampered by the decreased expression of the sodium iodide symporter (NIS) in DTC during the process of dedifferentiation. At present, there are no effective therapies available for RaI non-avid DTC. Conventional chemotherapy is hardly effective in DTC, and no longer recommended in international guidelines. In DTC, many genetic alterations have bee...

ea0016oc1.3 | Neuroendocrinology and pituitary | ECE2008

Limited effects of growth hormone replacement in adults with growth hormone deficiency after treatment for acromegaly

van der Klaauw Agatha , Bax Jeroen , Stokkel Marcel , Bleeker Gabe , Roelfsema Ferdinand , Smit Johannes , Romijn Johannes , Pereira Alberto

Growth hormone deficiency (GHD) can occur after treatment for acromegaly. It is unclear whether treatment with recombinant human growth hormone (rhGH) in these patients is beneficial. Patients were randomized to either 1 year of rhGH replacement (n=10) or placebo followed by rhGH replacement for 1 year (delayed rhGH treatment, n=6). Sixteen patients (8 men, mean age 56 years) with GHD after treatment for acromegaly were studied. Study parameters were assessed at ...

ea0049gp197 | Thyroid 1 | ECE2017

Cognitive functions in primary hypothyroidism on selenium supplementation

Nikolic-Djurovic Marina , Pereira Alberto , Smit Johannes , Vasovic Olga , Jemuovic Zvezdana , Damjanovic Svetozar , Asanin Milika , Pavlovic Dragan , Jankovic Dragana , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Petakov Milan

Introduction: Selenium (Se) is a trace element that plays key roles in thyroid pathology. In patients with Hashimoto thyroiditis (HT), Se supplementation might reduce antibody levels and may provide additional beneficial effects, such as on cognition.Aim: To evaluate cognitive function (cognitive decline) in patients on long-term levothyroxine replacement for primary hypothyroidism with and without selenium supplementation.Design: ...

ea0020p545 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Pre-treatment IGF-I concentrations predict radiographic osteoarthritis in acromegalic patients with long-term cured disease

Biermasz Nienke R , Wassenaar Moniek J E , van der Klaauw Agatha A , Pereira Alberto M , Smit Johannes W A , Roelfsema Ferdinand , Wolterbeek Ron , Kroon Herman M , Kloppenburg Margreet , Romijn Johannes A

Objective: To identify factors influencing the development of osteoarthritis during long-term control of acromegaly, focusing on disease specific parameters, growth hormone (GH) and insulin-like growth factor I (IGF-I) concentrations and duration of disease, adjusted for the well-known determinants of primary osteoarthritis.Design: Follow-up study.Methods: We studied 67 patients, with adequate biochemical control of acromegaly for ...

ea0092op-05-04 | Oral Session 5: Young Investigators / Basic | ETA2023

Multi-Trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

Sterenborg Rosalie , Steinbrenner Inga , Li Yong , Bujnis Melissa , Naito Tatsuhiko , Marouli Eirini , Consortium Thyroidomics , Kottgen Anna , Smit Johannes W.A. , Peeters Robin , Teumer Alexander , Medici Marco

Introduction: In the last decade, it has become clear that not only overt but also subclinical hypo- and hyperthyroidism are associated with several adverse clinical outcomes, including atrial fibrillation, coronary heart disease, stroke and mortality. More recently, various studies have suggested that even small differences in thyroid function within the reference range are associated with clinical consequences. Genetic factors are responsible for up to 58-71% of the variatio...

ea0041oc14.2 | Thyroid Cancer | ECE2016

Complex immunometabolic pathways mediate the interaction between thyroid carcinoma cells and tumor-associated macrophages

Arts Rob , Plantinga Theo , Heinhuis Bas , Tuit Sander , Petrulea Mirela , Tesselaar Marika , Sloot Yvette , Kusters Benno , Joosten Leo , Georgescu Carmen , Smit Johannes , Netea Mihai , Schulze Joakim , Netea-Maier Romana

Background: Tumor-associated macrophages (TAMs) with dysregulated inflammatory phenotypes play a key role in carcinogenesis. In thyroid carcinoma (TC), excessive release of proinflammatory cytokines decreases the expression of sodium-iodine transporter and inflammation potentiates tumor progression.Aim: To assess the impact of TC cells on the functional reprograming of TC-induced macrophages at the level of transcriptome and metabolic pathways, and asses...

ea0020p552 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The D3 GH receptor polymorphism is associated with osteoarthritis, especially of the hip, in patients with long-term cured acromegaly

Wassenaar Moniek JE , Biermasz Nienke R , van der Klaauw Agatha A , Smit Johannes WA , Pereira Alberto M , Roelfsema Ferdinand , van der Straaten Tahar , Kroon Herman M , Kloppenburg Margreet , Guchelaar HJ , Romijn Johannes A

Objective: To evaluate the impact of the genomic deletion of exon 3 in the growth hormone receptor (d3GHR) on co-morbidities of acromegaly in a well-characterized cohort of patients with long-term remission of acromegaly.Design: Cross sectional study.Methods: The presence of the d3GHR polymorphism was assessed in 86 acromegalic patients and related to clinical outcome, i.e. anthropometric parameters, osteoarthritis, and the metabol...