Searchable abstracts of presentations at key conferences in endocrinology

ea0055wg5 | Workshop G: Disorders of the parathyroid glands, calcium metabolism and bone | SFEEU2018

Multifactorial hypocalcaemia in a patient presenting with sepsis

Rajkumar Santoshkumar , Smith Andrew

Hypocalcaemia is one of the common metabolic abnormalities found in hospitalised patients. The most common cause of hypocalcaemia is Vitamin D deficiency. Others causes include hypoparathyroidism, chronic kidney disease and hypomagnesemia. Multiple factors can co-exist in the same patient. We present here a case of hypocalcaemia caused by multiple factors in the same patient. The patient we present probably had multiple factors contributing to hypocalcaemia. Our hypothesis is ...

ea0044p246 | Thyroid | SFEBES2016

High tumoral expression of PBF and PTTG modulates the DNA damage response and is associated with poor survival in thyroid cancer

Read Martin , Fong Jim , Imruetaicharoenchoke Waraporn , Nieto Hannah , Modasia Bhavika , Fletcher Alice , Thompson Rebecca , Sharma Neil , Bacon Andrea , Watkinson John , Boelaert Kristien , Turnell Andrew , Smith Vicki , McCabe Christopher

Despite extensive genomic profiling a better understanding of the contributory factors that promote aggressive thyroid cancer is urgently needed. The proto-oncogenes PBF and PTTG have been implicated in thyroid cancer but there is a lack of information regarding their co-expression and specific roles in tumour progression. Separate studies have previously indicated that PBF and PTTG may disrupt pathways associated with the tumour suppressor p53 that are central to DNA-damage r...

ea0059p119 | Neoplasia, cancer & late effects | SFEBES2018

Oncogenic action of pituitary-tumor transforming gene (PBF) in head and neck cancer is associated with poorer overall survival

Read Martin , Modasia Bhavika , Fletcher Alice , Thompson Rebecca , Baker Katie , Nieto Hannah , Campbell Moray , Boelaert Kristien , Turnell Andrew , Smith Vicki , Mehanna Hisham , McCabe Christopher

PBF is a multifunctional proto-oncogene overexpressed in thyroid and other endocrine cancers. Previously we identified a functional interaction between PBF and the tumour suppressor p53 in well-differentiated thyroid cancer (WDTC). Here, we delineate the oncogenic mechanisms of PBF, along with its binding partner PTTG, in head and neck cancer (HNSCC), in which TP53 mutations (mutTP53) are common (>50%). HNSCC tissue revealed significant upregulation of PBF and PTTG mRNA (&...