Searchable abstracts of presentations at key conferences in endocrinology

ea0009p189 | Clinical | BES2005

Myelinolysis following the treatment of Addisonian crisis

Lockett H , Smith J , Dyer R , Crook N

Myelinolysis is a recognised complication following over-rapid correction of hyponatraemia. However, the risk of myelinolysis following the treatment of Addisonian crisis is rarely reported. We report 2 cases of primary adrenal insufficiency (PAI) both associated with severe hyponatraemia. In the first case, myelinolysis developed following treatment with corticosteroids and isotonic saline in line with current recommendations. In the second case, deliberately cautious correct...

ea0028p192 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

The role of metabolic dyslipidaemia in screening for impaired glucose regulation in polycystic ovary syndrome

Aye Myint M , Kahal Hassan , Smith H , Sandeman D , Kilpatrick Eric , Atkin S

Background: Women with polycystic ovary syndrome (PCOS) are commonly associated with insulin resistance, metabolic syndrome and a family history of diabetes mellitus (DM). They are therefore at risk of diabetes and dyslipidaemia. Diabetes UK (2006) recommends screening for diabetes in PCOS patients who have a body mass index (BMI) ≥30. The recommended test is fasting plasma glucose (FPG). We therefore investigated 55 PCOS patients and 33 healthy volunteers to test the hy...

ea0009p75 | Growth and development | BES2005

A comparison of vascular reactivity in postmenopausal women receiving testosterone and conventional HRT versus conventional HRT

Lane H , Smith J , Davies N , Cockcroft J , Morris K , Scanlon M , Davies J

Backround: Recent research has heightened the controversy surrounding the effects of conventional hormone replacement therapy on cardiovascular risk, suggesting that use of HRT is associated with an increase in cardiovascular morbidity and mortality. Testosterone has also been associated with unfavourable cardiovascular parameters and the addition of testosterone to HRT may augment the risk of cardiovascular events in postmenopausal women.Aim: To elucida...

ea0005p246 | Steroids | BES2003

Testosterone reduces free radical release from human monocytes

Lane H , Smith J , Rathbone N , Morris K , Thomas A , Scanlon M , Davies J

Background: Although androgens are traditionally considered to be pro-atherogenic, there is increasing evidence to suggest an inverse relationship between testosterone and cardiovascular risk. Endothelial dysfunction is an early event in the process of atherogenesis and may occur as a result of vascular oxidative damage. In vivo, human monocytes release reactive oxygen intermediates as part of a normal immune response.Aim: This study assessed the contribution of testostero...

ea0086oc5.6 | Metabolism, Obesity and Diabetes | SFEBES2022

Labelling and characterisation of somatostatin secreting D-Cells in primary human duodenal organoids culture

Bany Bakar Rula , Sayda Mariwan H. , Smith Christopher A. , Guccio Nunzio , Kay Richard , Gribble Fiona M. , Reimann Frank

Backgrounds and aims: Enteroendocrine cells (EECs) are hormone-secreting cells within the intestinal epithelium that play an important role in regulating food absorption, insulin secretion and appetite. The somatostatin (SST)-producing D-cell is an EEC of particular interest due to the profound inhibition exerted by SST over other EECs, highlighting D-cells as critical regulator of the enteroendocrine axis. The aim of this study was to profile the transcriptom...