Searchable abstracts of presentations at key conferences in endocrinology

ea0009p227 | Clinical | BES2005

An audit of the management of primary hyperparathyroidism

McDermott J , Smith C , Sreenan S

We audited the management of primary hyperparathyroidism (PHP) at our institution between 2000 and June 2004, to determine our adherence to the Consensus Development Conference on the Management of Asymptomatic PHP (2002) guidelines.Sixteen patients were referred with PHP during the period in question, 12 female. Average age at diagnosis was 59 years (range 36-81), average PTH level 155 ng/mL, and average corrected serum calcium 2.76 mmol/L (normal 2.1-2...

ea0007p178 | Reproduction | BES2004

Routine screening for macroprolactin

Gibney J , Smith T , McKenna T

Macroprolactin has reduced bioactivity and accumulates in the sera of some subjects, resulting in apparent hyperprolactinaemia. Development of the polyethyleneglycol (PEG) precipitation technique has enabled large-scale screening for macroprolactin in hyperprolactinaemic subjects. We have reviewed the experience of routine screening for macroprolactin using PEG precipitation over a 54-month period in a single centre.Plasma levels of prolactin exceeded 50...

ea0007p221 | Steroids | BES2004

Mineralocorticoid replacement in patients with primary hypoadrenalism; does plasma renin concentration help in practice

Anthony S , Madathil A , Smith J , Chapman J

Replacement mineralocorticoid(MC)therapy in patients with primary hypoadrenalism is titrated according to clinical and /or biochemical criteria. No single objective assessment is adequate for monitoring,though targets for plasma renin and serum electrolyte concentrations and blood pressure(BP)have been proposed.Plasma renin concentrations within the middle to upper normal range would suggest adequate MC replacement. We reviewed the case notes of 18 patients in order to identif...

ea0009p15 | Diabetes and metabolism | BES2005

Prostaglandin synthesis in adipose tissue from women with simple obesity - differences between omental and subcutaneous depots

Quinkler M , Bujalska I , Tomlinson J , Smith D , Stewart P

Prostanoids have been elucidated as potent adipogenic hormones. Cyclooxygenase (PTGS) is the rate-limiting enzyme of prostanoid biosynthesis and its product, prostaglandin (PG) H2 is a precursor of PGE2, PGF2, PGD2 and PGI2. PGH2 is also metabolised by prostaglandin D-synthase (PTGDS) to PGD2 which spontaneously converts to PGJ2 or can be enzymatically converted to PGF2alpha by AKR1C3. These two metabolites have opposite effect on adipogenesis; PGF2alpha is a PPARgamma antagon...

ea0009p189 | Clinical | BES2005

Myelinolysis following the treatment of Addisonian crisis

Lockett H , Smith J , Dyer R , Crook N

Myelinolysis is a recognised complication following over-rapid correction of hyponatraemia. However, the risk of myelinolysis following the treatment of Addisonian crisis is rarely reported. We report 2 cases of primary adrenal insufficiency (PAI) both associated with severe hyponatraemia. In the first case, myelinolysis developed following treatment with corticosteroids and isotonic saline in line with current recommendations. In the second case, deliberately cautious correct...

ea0003p242 | Signalling | BES2002

Essential role of p38 mitogen-activated protein kinase in adipogenesis

Patel N , Holder J , Smith S , Kumar S , Eggo M

Human obesity is characterised by an increase in both the number of adipocytes and by an increase in their size, which is determined by adipogenesis. Adipogenesis can be induced in vitro in preadipocytes cultured in differentiation medium containing 3-isobutyl-1-methylxanthine, insulin, dexamethasone, and triiodothyronine but the signalling pathways important in adipogenesis are not well characterised. The p38 mitogen-activated protein kinase (MAPK) signalling pathway i...

ea0047oc50 | Innovative Theranostics | Theranostics2016

Radiolabel results from high specific activity e-LINAC produced 67Cu

Stoner Jon L , Gardner Tim J , Smith Suzanne , Jeffery Charmaine , Harris Matt

We developed an improved process for producing high quality 67Cu using an electron accelerator instead of a high energy proton accelerator. The beta/gamma emitting radioisotope 67Cu was created using the (g,p) reaction on isotopically enriched 68Zn target (nominally 40 g, 98% enrichment). The high energy photons were produced by bremsstrahlung conversion of electrons from a 45 MeV electron LINAC. A specially designed water cooled converter, end...

ea0030p29 | (1) | BSPED2012

Should we check vitamin D status at time of diagnosis of type 1 diabetes mellitus?

Smith J P , Crowne E , Hamilton-Shield J P H , Burren C

Physiology shows vitamin D has a role in the immune system and glucose metabolism. Experimental and epidemiological studies demonstrate associations between type 1 diabetes mellitus (T1DM) and vitamin D levels. Vitamin D deficiency appears undesirable in T1DM, although its significance in aetiology and progression is controversial.We reviewed the outcome of implementing vitamin D screening at T1DM diagnosis. Methods were review of diabetes register, hosp...

ea0011p850 | Thyroid | ECE2006

Association of the FCRL3 gene with Graves’ disease in the UK Caucasian population

Simmonds MJ , Heward JM , Carr-Smith J , Franklyn JA , Gough SCL

Recently, linkage between chromosome 1q23 and rheumatoid arthritis within the Japanese population has been narrowed down to association of four single nucleotide polymorphisms (SNPs), fcrl3_3, fcrl3_4, fcrl3_5 and fcrl3_6, within FCRL3, a known regulator of B cell signalling. Of these four SNPs, fcrl3_3 was shown to disrupt FCRL3 expression on B cells, suggesting a potential etiological role. Association of fcrl3_3 was also replicated in a Japanese GravesÂ’ disease ...