Searchable abstracts of presentations at key conferences in endocrinology

ea0009p43 | Growth and development | BES2005

Kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis in adult male rats following central and peripheral administration

Thompson E , Patterson M , Murphy K , Smith K , Dhillo W , Todd J , Ghatei M , Bloom S

Kisspeptin is the peptide product of the KiSS-1 gene and endogenous agonist for the GPR54 receptor. The kisspeptin/GPR54 system has recently been suggested as a key regulator of the reproductive system. GPR54 deficient mice have abnormal sexual development and low circulating gonadotrophins and in humans, GPR54 mutations have been shown to cause hypogonadotrophic hypogonadism. Thus, GPR54 appears to be essential for normal gonadotrophin secretion and the regulation of puberty....

ea0010p94 | Thyroid | SFE2005

A UK wide survey of post-operative thyroid surgical practice and life threatening complications

Smith K , Ridgway L , Mihaimeed F

Objective: To improve post-operative thyroid surgery practice and to determine if it would be safe to perform thyroid surgery as day surgery. To identify the nature and timings of acute life threatening airway complications, trends in current practice, and gain information on perioperative mortality....

ea0002p28 | Diabetes and metabolism | SFE2001

Glucocorticoid excess leads to redistribution of available pyruvate from oxidation to maintain a normal rate of lactate formation via up-regulation of skeletal-muscle pyruvate dehydrogenase kinase 4 expression

Holness M , Bulmer K , Smith N , Sugden M

Insulin resistance is an established consequence of glucocorticoid excess. In rats, administration of the synthetic glucocorticoid dexamethasone decreases the sensitivity of glucose oxidation to insulin in soleus muscle strips, but sensitivity of lactate formation is unimpaired. In rats, cortisol impairs pyruvate tolerance and, in man, dexamethasone decreases whole-body glucose oxidation. The present study explored possible mechanisms that might underlie these effects. Activat...

ea0036P81 | (1) | BSPED2014

A case report of TRβ mutation leading to raised T4 levels presenting with abnormal body habitus

Tomlinson N D , Banerjee I , Chatterjee K , Smith T D , Mukherjee A

Introduction: We present a 5-year-old girl with thyroid hormone resistance, subsequently discovered to be heterozygous for TRβ mutation. This case highlights the necessity to investigate, in detail, all children with persistently high thyroxin with normal TSH levels in order to aid future management and the necessity to follow them up.Case report: SD was born at term by normal delivery weighing 3.34 kg (50th centile). She was referred at 6 months of...

ea0029p1101 | Neuroendocrinology | ICEECE2012

Genetic variation of the hypothalamo-pituitary axis may increase susceptibility of postnatal depression

Engineer N. , Darwin L. , Deole N. , Ngianga-Bakwin K. , Smith S. , Grammatopoulos D.

Objective: To investigate whether genetic variants in the glucocorticoid receptor (GR) and corticotropin releasing hormone receptor 1 (CRHR1) genes are associated with increased susceptibility for postnatal depression (PND).Methods: A prospective longitudinal cohort study at University Hospital, Coventry, England. Two hundred pregnant women were recruited and assessed for PND using the Edinburgh postnatal depression score (EPDS) upon recruitment and agai...

ea0009p124 | Endocrine tumours and neoplasia | BES2005

Central Relaxin-3 administration causes hyperphagia in male Wistar rats

McGowan B , Stanley S , Smith K , White N , Connolly M , Gardiner J , Ghatei M , Bloom S

Relaxin-3 (INSL-7) is a recently discovered member of the insulin superfamily, a group of structurally related hormones whose precursors have a domain arrangement similar to that of pro-insulin. Relaxin-3 mRNA is expressed in the nucleus incertus of the brainstem which has projections to the hypothalamus, an area important in appetite regulation. Relaxin-3 binds with high affinity to the recently discovered previously orphan G-protein-coupled receptor, GPCR135, which is expres...

ea0005p180 | Neuroendocrinology and Behaviour | BES2003

Intra-hypothalamic gene transfer of cocaine and amphetamine regulated-transcript results in increased food intake and weight gain

Ward H , Gardiner J , Smith K , Kong W , Martin N , Small C , Ghatei M , Bloom S

Cocaine and amphetamine regulated-transcript (CART) is highly expressed in the hypothalamus and was originally reported to be an endogenous satiety peptide. Intracerebroventricular injection of CART can result in motor abnormalities and recent studies have demonstrated increased food intake after intra-nuclear CART administration. To help clarify the situation CART was over-expressed in the hypothalamus using recombinant adeno-associated virus (rAAV-CART). Recombinant adeno-as...

ea0015p240 | Pituitary | SFEBES2008

The short and long-term effect of growth hormone (GH) replacement therapy on quality of life in adults with severe growth hormone deficiency

Behan Lucy Ann , Rogers Bairbre , Connolly Cara , Burrows Samantha , O'Sullivan Eoin P , Crowley Rachel K , Smith Diarmuid , Agha Amar

Adult GH deficiency is associated with poor quality of life (QoL) which has been shown to improve with GH replacement is some but not all, mainly short-term studies. In addition, it remains unclear whether this improvement in QoL is sustainable.We aimed to establish the short and long-term effect of GH replacement on QoL in 167 adult patients with severe GH deficiency in a prospective study. QoL was assessed using the quality of life-assessment of growth...

ea0007p137 | Growth and development | BES2004

Frequency of single nucleotide polymorphisms in the GHRH receptor gene in short children

Smith K , Gueorguiev M , Adams E , Mein C , Johnston L , Bonner S , Froguel P , Savage M , Grossman A , Korbonits M

A number of single nucleotide polymorphisms (SNPs) have been identified in the GHRH receptor gene. Two of these SNPs, A57T and V225I, have been found to cause an increased cAMP response to GHRH stimulation in vitro, and it has been suggested that they may be associated with the abnormal biochemistry in patients with somatotroph adenomas. The objective of this study was to clarify the frequencies of these SNPs in the normal population and in subjects with short stature. The sub...

ea0037ep89 | Adrenal cortex | ECE2015

Low DHEAS: a sensitive and specific screening test for the detection of subclinical hypercortisolism in adrenal incidentalomas

Dennedy Michael Conall , Anamalai Anand K , Smith Olivia Prankerd , Powlson Andrew S , Graggaber Johann , Shaw Ashley , Halsall David J , Gurnell Mark

Subclinical hypercortisolism (SH) occurs in 5–30% of incidentally-detected adrenal adenomas (AIs). Common screening tests for ACTH-independent hypercortisolism have significant false positive rates, mandating further investigations that are both time and resource intensive. We investigated whether a low basal DHEAS level is a sensitive and specific screening test for the detection/exclusion of SH in patients with newly-diagnosed AI. We recruited 185 consecutive patients w...