ea0065p346 | Reproductive Endocrinology and Biology | SFEBES2019
, Smith Lorna
, Jones Peter
, Bowe James
Previous studies have shown beneficial effects of the corticotropin releasing hormone (CRH) family, including the urocortins (UCN1, UCN2 and UCN3), on pancreatic islets and subsequent glucose homeostasis. However, the physiological relevance of this interaction is not currently understood. CRH and urocortins are also expressed by placenta, so this study investigated whether signalling through CRH receptor 1 or 2 (CRHR1/CRHR2) plays a role in the islet adaptation to pregnancy. ...