Searchable abstracts of presentations at key conferences in endocrinology

ea0022p235 | Clinical case reports and clinical practice | ECE2010

Carbimazole induced neutropenia: are we too cautious?

Smith Robert , Saraf Sanjay , Madhusudana Kattepura , Katreddy Mahesh , Ashawesh Khaled

Carbimazole is a commonly used antithyroid drug with a rare but potentially life-threatening side effect of agranulocytosis. We present a case of a 47-year-old lady who was diagnosed with hyperthyroidism four years previously and treated with carbimazole despite persistent neutropenia.At diagnosis the patient had clinical features of hyperthyroidism and thyroid function test (TFT) showed free T4 40.8 pmol/l (10.6–21.0), free T3...

ea0022p236 | Clinical case reports and clinical practice | ECE2010

Carbimazole pseudo-resistance: two case reports

Madhusudana Kattepura , Saraf Sanjay , Smith Robert , Katreddy Mahesh , Ashawesh Khaled

Introduction: Weight gain following treatment of hyperthyroidism is well recognised. This may lead to compliance problems both in patients with/without eating disorders and subsequent failure of therapy. We describe two cases where this was successfully managed with supervised in-patient therapy.Case 1: A 30-year-old overweight lady was diagnosed with Grave’s disease following childbirth. Thyroid function test (TFT) at initiation of treatment showed...

ea0013s34 | Animal disease, paradigm for human conditions | SFEBES2007

Stress and sex on the farm – lessons for humans

Dobson Hilary , Walker Susan , Ghuman Sarvpreet , Smith Robert

Research in farm animals has long been a cornerstone of our understanding of reproduction and holds similar opportunities for understanding mechanisms by which stress affects fertility. Sheep and cow experimental models are appropriate to humans, especially as detailed longitudinal studies are possible because of size and access to ovaries.Failure to realise genetic potential is a better definition of stress than ‘an increase in corticoids’; ma...

ea0031p154 | Neoplasia, cancer and late effects | SFEBES2013

PBF overexpression causes increased p53 ubiquitination and degradation via MDM2

Ryan Gavin , Read Martin , Seed Robert , Smith Vicki , Fong Jim , Turnell Andrew , Franklyn Jayne , McCabe Christopher , Boelaert Kristien

The pituitary tumor-transforming gene-binding factor (PBF) is a relatively uncharacterised proto-oncogene, which is overexpressed in thyroid tumours. PBF elicits tumor growth in nude mice, whilst thyroid targeted transgenic overexpression in the PBF-Tg mouse induces hyperplasia and macrofollicular lesions, accompanied by induction of the E2 ubiquitin ligase Rad6. Our previous unpublished data showed that PBF binds to p53, and reduces stimulation of downstream target genes by c...