Searchable abstracts of presentations at key conferences in endocrinology

ea0024p34 | (1) | BSPED2010

Undefined diabetes unfolds

Senniappan S , Smith C

Introduction: Although type 1 diabetes is the most common type of diabetes in children, with the steady increase in type 2 and rare forms of diabetes, it may be sometimes difficult to ascertain the type of diabetes at the time of presentation. Some children present with a combination of features and do not fit into one of the classical types of diabetes. The rapid progress in the molecular genetics has helped to identify the specific diagnosis for these rare forms of diabetes....

ea0024p31 | (1) | BSPED2010

An unusual case of diabetes complicated by massive insulin oedema following onset of insulin therapy

Aravamudhan A , Senniappan S , Smith C

Insulin oedema is uncommon and poorly understood. It has been reported mainly in the adult literature. We present one of the youngest cases reported in the literature.A previously obese 9-year-old boy gradually lost weight over 18-month period and experienced polyuria and polydipsia for several months. He presented in diabetic ketoacidosis (blood glucose 24 mmol/l, pH 7.13, bicarbonate 6.6 mmol/l, potassium 3.13 mmol/l, urinary ketones 3+) which resp...

ea0003p108 | Diabetes & Metabolism | BES2002

Paediatric diabetes survey shows type 2 diabetes prevalence 0.4%, distinct from type 1, and associated with overweight, puberty, female sex and ethnic minority status

Barrett T , Ehtisham S , Smith A , Hattersley A

Most children with diabetes are insulin deficient (type 1). We have reported type 2 diabetes in children, defined by evidence of insulin resistance, but the prevalence and characteristics in UK children is unknown. We aimed to characterise and determine the prevalence of non-type 1 diabetes in the UK. The British Society for Paediatric Endocrinology and Diabetes Clinical Trials unit undertook a cross-sectional questionnaire survey of all paediatric diabetes centres during 2000...

ea0009p100 | Endocrine tumours and neoplasia | BES2005

BRAF mRNA is over-expressed in pituitary adenomas, but the oncogenic BRAF mutation V5999E is not a frequent finding

Pedder-Smith S , Emery M , Musat M , Korbonits M , Grossman A

Sporadic pituitary tumours are generally benign tumours in which the none of the oncogenes or tumour suppressor genes classically mutated in other cancers are commonly mutated, nor are there frequent changes in genes associated with genetic endocrine neoplasia syndromes. Such tumours are associated with excessive but not completely unregulated proliferation, implicating a possible abnormality in a cell signalling pathway in their pathogenesis. Recently, the serine/threonine ki...

ea0003oc28 | Metabolism | BES2002

Rosiglitazone inhibits insulin-mediated rise in angiotensinogen expression and angiotensin II secretion in human subcutaneous adipocytes

Harte A , McTernan P , Smith S , Barnett A , Kumar S

The renin-angiotensin system (RAS)is important for the regulation of blood pressure with its blockade shown to reduce the vascular complications of diabetes. Adipose tissue expresses the RAS system and may contribute to obesity associated hypertension. Our previous in vitro studies have demonstrated that in human adipose tissue production of both angiotensinogen (AGT) and the active metabolite angiotensin II are stimulated by insulin. The present study investigated the ...

ea0003p242 | Signalling | BES2002

Essential role of p38 mitogen-activated protein kinase in adipogenesis

Patel N , Holder J , Smith S , Kumar S , Eggo M

Human obesity is characterised by an increase in both the number of adipocytes and by an increase in their size, which is determined by adipogenesis. Adipogenesis can be induced in vitro in preadipocytes cultured in differentiation medium containing 3-isobutyl-1-methylxanthine, insulin, dexamethasone, and triiodothyronine but the signalling pathways important in adipogenesis are not well characterised. The p38 mitogen-activated protein kinase (MAPK) signalling pathway i...

ea0003p261 | Steroids | BES2002

Angiotensin II and ACTH differentially regulate adrenal steroid production through key steroidogenic enzymes

Kelly S , Smith T , Cunningham S , Young L , McKenna T

The adrenal cortex produces aldosterone, cortisol and adrenal androgens. ACTH regulates the production of both cortisol and adrenal androgens. However there are physiological and pathophysiological conditions where the production of these steroids is divergent. We examined the effect angiotension II (A-II) and insulin on the relative production of cortisol and adrenal androgens in the human adrenal H-295 cell line. We determined the ability of these secretogogues to regulate t...

ea0003p262 | Steroids | BES2002

A role for nur-77 in the regulation of adrenal steroid production

Kelly S , Smith T , Cunningham S , McKenna T , Young L

The adrenal cortex produces aldosterone, cortisol and adrenal androgens in response to secretogogues including ACTH, angiotensin II(A-II) and insulin. Differential regulation of adrenal steroids is through the modulation of specific key steroidogenic enzymes. The capacity of the adrenal to produce cortisol is controlled in part by the transcription of 3beta-hydroxysteroiddehydrogenase (3beta HSD) and production of adrenal androgens by 17 hydroxylase/17-20 lyase (CYP17). Protei...

ea0002oc15 | Neuroendocrinology | SFE2001


Theogaraj E , John C , Smith S , Buckingham J

Perinatal glucocorticoid (GC) treatment accelerates lung maturation but may compromise health in adulthood, possibly via changes in hypothalamo-pituitary adrenal (HPA) activity. This study used western blot analysis and a well established in vitro method to investigate the effects of perinatal GC treatment on the expression and function of annexin 1 (ANXA1), a 37kDa protein which mediates facets of GC action in the neuroendocrine and host defence systems. Male rats were treate...

ea0086p175 | Adrenal and Cardiovascular | SFEBES2022

Neonatal salt wasting: A rare case of X-linked adrenal hypoplasia congenita

Frank Amy R , Longmuir Sophie , McNeilly Jane , McGowan Ruth , Faisal Ahmed S , Smith Karen

Neonatal salt wasting can present in neonates with a life-threatening state of hyponatraemia, hyperkalaemia, dehydration and metabolic acidosis. The differential diagnosis of neonatal salt wasting includes congenital adrenal hyperplasia (CAH) most commonly due to 21-hydroxylase deficiency, pseudohypoaldosteronism (PHA), X-linked adrenal hypoplasia congenital (AHC) and aldosterone synthase defects. Diagnostic work up should include serum measurement of ACTH, Cortisol, 17OH-prog...