Searchable abstracts of presentations at key conferences in endocrinology

ea0044ep77 | (1) | SFEBES2016

A patient who presented unresponsive and unseated from the sella

Stammers Kathryn , Solomon Andrew

Case History-A 74 year old female patient presented to the emergency department following a witnessed seizure and profound hypoglycaemia (BM 1.1 mmol/l) with an initial GCS of 7/15. Collateral history described 4 days’ feeling unwell with reduced oral intake and multiple recent ‘vacant episodes’. An urgent CT head was unremarkable. Past medical history included hypothyroidism of several years’ duration on T4 50 mcg [3 months’ prior to admission, TSH wa...

ea0069p30 | Poster Presentations | SFENCC2020

ADHD and Addison’s: similar in name, similar in nature?

Yin Su Lei , Solomon Andrew , Joharatnam Jalini

Section 1: Case history: An 18 year old young man with a background of several years’ ADHD (Attention Deficit Hyperactivity Disorder) and moderate learning disability presented generally unwell, with recent weight loss, abdominal pain, vomiting and poor oral intake in May 2019. He had been unsettled for some time with his mother convinced that his current condition warranted further investigation. When blood tests were done, severe hyponatraemia and hyperkalaemia were fou...

ea0034p108 | Clinical practice/governance and case reports | SFEBES2014

Improving the quality of endocrinology teaching to clinical medical students

Vega Philippa , Gishen Faye , Solomon Andrew

Background: This project endeavoured to improve the quality of endocrinology teaching to clinical medical students through the use of a new multi-stage process.Methods: We created a co-ordinated block containing 4-h teaching sessions (4×1 h) in which eight students in their first clinical year presented answers to questions based on clinical endocrinology cases they had seen and selected. The process started with identification of cases in the out-p...

ea0034p168 | Neoplasia, cancer and late effects | SFEBES2014

A challenging case of hypokalaemic Cushing's crisis

Dunne Mary , Solomon Andrew , Swords Francesca

Background: Cushing’s syndrome derived from paraneoplastic ectopic ACTH production can present in dramatic fashion. We describe such a case that presented with severe hypokalaemia, involving significant diagnostic and management challenges.The case: A 66-year-old female was referred acutely to hospital by her GP after feeling weak and lethargic. She had profound hypokalaemia of 1.5 mmol/l (3.5–5.3) with normal renal function and had been normok...

ea0077lb55 | Late Breaking | SFEBES2021

Optimising diagnostic and management clarity in two opposing sodium centenarians

Chuluunbaatar Yanjinlkham , Dimassi Ahmad , Troke Rachel , Solomon Andrew

Introduction: Hyponatraemia is one of the most common electrolyte abnormalities seen in clinical practice [1] and can be caused by a myriad of aetiologies.Aim: To report two cases of severe hyponatraemia caused by different aetiologies.Case report: A 56-year-old male patient was admitted with 2 episodes of tonic-clonic seizures at his care home. The patient had a background of small cell lung cancer and brain metastases in late 202...

ea0038p108 | Clinical practice/governance and case reports | SFEBES2015

Separate, sequential, endocrine, and glycaemic effects of ipilimumab and pembrolizumab in metastatic melanoma

Anstey Julia , Solomon Andrew , Nathan Paul , Shaw Heather

Ipilimumab, pembrolizumab, and nivolumab – novel immune checkpoint blockade drugs – are increasingly used in the treatment of metastatic melanoma and other cancers. Ipilimumab is an anti-cytotoxic T-lymphocyte antigen 4 (CTLA4) MAB and the first drug shown to improve overall survival in metastatic melanoma. Hypophysitis is a widely described side-effect linked with both lymphocytic inflammation and a direct toxic effect on the pituitary in mouse studies, but has been...

ea0050cc03 | Featured Clinical Cases | SFEBES2017

A novel variant in the androgen receptor gene causing familial mild androgen insensitivity syndrome

Iacovazzo Donato , Kumar Ajith , Abbs Stephen , Solomon Andrew , Korbonits Marta , Druce Maralyn

Introduction: Androgen insensitivity syndrome (AIS) is a heterogeneous condition. At the milder end of the clinical spectrum, patients with mild AIS (MAIS) are phenotypically male, and may present with infertility, either isolated or associated with gynaecomastia or signs of mild undervirilization. Most cases of complete and approximately 25% of partial AIS patients harbour mutations in the androgen receptor (AR) gene. Over 1,000 pathogenic variants have been describe...

ea0050cc03 | Featured Clinical Cases | SFEBES2017

A novel variant in the androgen receptor gene causing familial mild androgen insensitivity syndrome

Iacovazzo Donato , Kumar Ajith , Abbs Stephen , Solomon Andrew , Korbonits Marta , Druce Maralyn

Introduction: Androgen insensitivity syndrome (AIS) is a heterogeneous condition. At the milder end of the clinical spectrum, patients with mild AIS (MAIS) are phenotypically male, and may present with infertility, either isolated or associated with gynaecomastia or signs of mild undervirilization. Most cases of complete and approximately 25% of partial AIS patients harbour mutations in the androgen receptor (AR) gene. Over 1,000 pathogenic variants have been describe...

ea0074ncc35 | Highlighted Cases | SFENCC2021

Challenges in managing toxic multinodular goitre and propylthiouracil-induced anti-neutrophil cytoplasmic antibody associated vasculitis

Koysombat Kanyada , Rehman Zahra , Aung Htet Htet , Elmustafa Sarra , Lin Nyan , Zac-Varghese Sagen , Solomon Andrew

Case history: A 53-year-old woman presented with vasculitic rash affecting her limbs. She has a 3-year history of thyrotoxicosis. Having developed intolerance to carbimazole she was maintained on propylthiouracil (PTU) for the last two years. Imaging results were consistent with multinodular goitre. Thyroid stimulating immunoglobulin was negative. A few months prior to this presentation she developed dysphagia. Repeat imaging showed an 8 cm right thyroid nodule that grew signi...

ea0065p436 | Thyroid | SFEBES2019

Amiodarone induced thyroiditis in congenital heart disease – how long should we continue steroids?

Yin Yin , Anyiam Oluwaseun , Kaplan Felicity , Al-Sabbagh Samer , Solomon Andrew , Palazzo Fausto , Meeran Karim , Joharatnam Jalini

A 38-year male with background history of Tetralogy of Fallot which had been surgically corrected, presented with symptomatic supraventricular tachycardia in July 2015. This required amiodarone therapy. Thyroid function was normal prior to starting amiodarone. Amiodarone therapy was discontinued in July 2017 when he converted to sinus rhythm. Seven months after stopping treatment, he presented to A&E with signs and symptoms of hyperthyroidism. His TSH was <0.03 mU/l (0...