Searchable abstracts of presentations at key conferences in endocrinology

ea0092op-01-01 | Oral Session 1: Highlights in Thyroidology: in Memory of Jacques Dumont | ETA2023

Patient-Derived medullary thyroid cancer organoids; a model for patient-tailored drug and tracer screening

Jager Eline , Sondorp Luc , Antunes Ines , Jansen Liesbeth , Brouwers Adrienne , Links Thera , Coppes Robert , Kruijff Schelto

Background: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor derived from the parafollicular C-cells of the thyroid gland. Mutations in the gene encoding the Rearranged during Transfection (RET) tyrosine kinase, play a vital role in the development of MTCs. In patients with distant metastases, only targeted therapy can prolong survival. Tyrosine kinase inhibitors (TKIs) block tyrosine kinases such as RET and thereby inhibit tumor proliferation. However, it is diffic...